Uniform ethyl cellulose microspheres of controlled sizes and polymer viscosities and their drug-release profiles

Young Bin Choy, Hyungsoo Choi, Kyekyoon Kim

Research output: Contribution to journalArticle

Abstract

Monodisperse ethyl cellulose (EC) microspheres (MSs) of three size groups (20-35, 55-60, and 80-105 μm in diameter) were fabricated to study the effect of the MS size on the drug-release profiles with a novel scheme combining mechanical and hydrodynamic forces. More than 90% of the MSs were within ±3 μm of the average diameter, regardless of the EC viscosities used in the study. The effect of the polymer viscosity was also examined with ECs with two distinct viscosities (4 and 45 cp). The encapsulation efficiencies (EEs) of piroxicam and rhodamine were 6.4-51 and 63-80%, respectively. The drug distribution in the MSs showed a higher concentration near the particle surface, and this was more distinct with rhodamine. An approximately zero-order release was observed with the small MSs of 4-cp EC during 24 h without evident initial bursts. The MS size affected the surfacearea-to-volume ratio, EE, and intraparticle drug distribution, affecting the drug-release profiles.

Original languageEnglish (US)
Pages (from-to)850-857
Number of pages8
JournalJournal of Applied Polymer Science
Volume112
Issue number2
DOIs
StatePublished - Apr 15 2009

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Microspheres
Cellulose
Polymers
Viscosity
Pharmaceutical Preparations
Rhodamines
Encapsulation
Piroxicam
ethyl cellulose
Hydrodynamics

Keywords

  • Biopolymers
  • Drug delivery systems
  • Microencapsulation
  • Processing

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics
  • Surfaces, Coatings and Films
  • Chemistry(all)

Cite this

Uniform ethyl cellulose microspheres of controlled sizes and polymer viscosities and their drug-release profiles. / Choy, Young Bin; Choi, Hyungsoo; Kim, Kyekyoon.

In: Journal of Applied Polymer Science, Vol. 112, No. 2, 15.04.2009, p. 850-857.

Research output: Contribution to journalArticle

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