Uniform chitosan microspheres for potential application to colon-specific drug delivery

Young Bin Choy, Felice Cheng, Hyungsoo Choi, Kyekyoon Kim

Research output: Contribution to journalArticle

Abstract

Uniform chitosan microspheres have been fabricated and weakly crosslinked for potential applications in colon-specific drug delivery. The effects of microsphere size, crosslinking density and electrostatic interactions between the drug and chitosan on drug release were studied, employing model drugs of different acidities. When the drug was basic, all chitosan spheres exhibited 100% release within 30 min. As the acidity of the drug increased, the release slowed down and depended on the crosslinking density and microsphere size. The release of weakly acidic drug was most suppressed for large spheres (35-38 μm), while the small spheres (23-25 μm) with higher crosslinking exhibited the most retention of highly acidic drug, indicating that they are a promising candidate for colon-specific delivery. A graph is presented.

Original languageEnglish (US)
Pages (from-to)1173-1181
Number of pages9
JournalMacromolecular Bioscience
Volume8
Issue number12
DOIs
StatePublished - Dec 8 2008

Fingerprint

Chitosan
Microspheres
Drug delivery
Crosslinking
Colon
Acidity
Pharmaceutical Preparations
Coulomb interactions
Static Electricity
Drug Interactions
Drug Liberation

Keywords

  • Biopolymers
  • Chitosan
  • Crosslinking
  • Drug delivery systems
  • Microencapsulation

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Uniform chitosan microspheres for potential application to colon-specific drug delivery. / Choy, Young Bin; Cheng, Felice; Choi, Hyungsoo; Kim, Kyekyoon.

In: Macromolecular Bioscience, Vol. 8, No. 12, 08.12.2008, p. 1173-1181.

Research output: Contribution to journalArticle

Choy, Young Bin ; Cheng, Felice ; Choi, Hyungsoo ; Kim, Kyekyoon. / Uniform chitosan microspheres for potential application to colon-specific drug delivery. In: Macromolecular Bioscience. 2008 ; Vol. 8, No. 12. pp. 1173-1181.
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