Uniform biodegradable hydrogel microspheres fabricated by a surfactant-free electric-field-assisted method

Young Bin Choy, Hyungsoo Choi, Kyekyoon Kim

Research output: Contribution to journalArticle

Abstract

Uniform biodegradable hydrogel microspheres (HMS) with precisely controlled size have been fabricated using an electric-field-assisted precision particle fabrication technique. Particle agglomeration was prevented by charging the hydrogel drops and allowing Coulomb repulsion to separate them. As a result, surfactant-free and non-toxic particle fabrication was possible and the resulting microspheres were most suitable for biomedical and food-related applications. Due to the size uniformity, the present HMS may serve as a convenient yet most accurate vehicle for controlled delivery of therapeutic agents and other active ingredients.

Original languageEnglish (US)
Pages (from-to)423-428
Number of pages6
JournalMacromolecular Bioscience
Volume7
Issue number4
DOIs
StatePublished - Apr 10 2007

Keywords

  • Biodegradable
  • Electric force
  • Hydrogels
  • Nontoxic
  • Uniform microspheres

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry
  • Bioengineering

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