Understanding the relationship between brain gene expression and social behavior: Lessons from the honey bee

Amro Zayed, Gene E. Robinson

Research output: Contribution to journalReview article

Abstract

Behavior is a complex phenotype that is plastic and evolutionarily labile. The advent of genomics has revolutionized the field of behavioral genetics by providing tools to quantify the dynamic nature of brain gene expression in relation to behavioral output. The honey bee Apis mellifera provides an excellent platform for investigating the relationship between brain gene expression and behavior given both the remarkable behavioral repertoire expressed by members of its intricate society and the degree to which behavior is influenced by heredity and the social environment. Here, we review a linked series of studies that assayed changes in honey bee brain transcriptomes associated with natural and experimentally induced changes in behavioral state. These experiments demonstrate that brain gene expression is closely linked with behavior, that changes in brain gene expression mediate changes in behavior, and that the association between specific genes and behavior exists over multiple timescales, from physiological to evolutionary.

Original languageEnglish (US)
Pages (from-to)591-615
Number of pages25
JournalAnnual Review of Genetics
Volume46
DOIs
StatePublished - Dec 3 2012

Fingerprint

Honey
Social Behavior
Bees
Gene Expression
Brain
Behavioral Genetics
Heredity
Social Environment
Genomics
Transcriptome
Plastics
Phenotype
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Understanding the relationship between brain gene expression and social behavior : Lessons from the honey bee. / Zayed, Amro; Robinson, Gene E.

In: Annual Review of Genetics, Vol. 46, 03.12.2012, p. 591-615.

Research output: Contribution to journalReview article

@article{3a571c6045d449a8b38d893a159ff4ff,
title = "Understanding the relationship between brain gene expression and social behavior: Lessons from the honey bee",
abstract = "Behavior is a complex phenotype that is plastic and evolutionarily labile. The advent of genomics has revolutionized the field of behavioral genetics by providing tools to quantify the dynamic nature of brain gene expression in relation to behavioral output. The honey bee Apis mellifera provides an excellent platform for investigating the relationship between brain gene expression and behavior given both the remarkable behavioral repertoire expressed by members of its intricate society and the degree to which behavior is influenced by heredity and the social environment. Here, we review a linked series of studies that assayed changes in honey bee brain transcriptomes associated with natural and experimentally induced changes in behavioral state. These experiments demonstrate that brain gene expression is closely linked with behavior, that changes in brain gene expression mediate changes in behavior, and that the association between specific genes and behavior exists over multiple timescales, from physiological to evolutionary.",
author = "Amro Zayed and Robinson, {Gene E.}",
year = "2012",
month = "12",
day = "3",
doi = "10.1146/annurev-genet-110711-155517",
language = "English (US)",
volume = "46",
pages = "591--615",
journal = "Annual Review of Genetics",
issn = "0066-4197",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Understanding the relationship between brain gene expression and social behavior

T2 - Lessons from the honey bee

AU - Zayed, Amro

AU - Robinson, Gene E.

PY - 2012/12/3

Y1 - 2012/12/3

N2 - Behavior is a complex phenotype that is plastic and evolutionarily labile. The advent of genomics has revolutionized the field of behavioral genetics by providing tools to quantify the dynamic nature of brain gene expression in relation to behavioral output. The honey bee Apis mellifera provides an excellent platform for investigating the relationship between brain gene expression and behavior given both the remarkable behavioral repertoire expressed by members of its intricate society and the degree to which behavior is influenced by heredity and the social environment. Here, we review a linked series of studies that assayed changes in honey bee brain transcriptomes associated with natural and experimentally induced changes in behavioral state. These experiments demonstrate that brain gene expression is closely linked with behavior, that changes in brain gene expression mediate changes in behavior, and that the association between specific genes and behavior exists over multiple timescales, from physiological to evolutionary.

AB - Behavior is a complex phenotype that is plastic and evolutionarily labile. The advent of genomics has revolutionized the field of behavioral genetics by providing tools to quantify the dynamic nature of brain gene expression in relation to behavioral output. The honey bee Apis mellifera provides an excellent platform for investigating the relationship between brain gene expression and behavior given both the remarkable behavioral repertoire expressed by members of its intricate society and the degree to which behavior is influenced by heredity and the social environment. Here, we review a linked series of studies that assayed changes in honey bee brain transcriptomes associated with natural and experimentally induced changes in behavioral state. These experiments demonstrate that brain gene expression is closely linked with behavior, that changes in brain gene expression mediate changes in behavior, and that the association between specific genes and behavior exists over multiple timescales, from physiological to evolutionary.

UR - http://www.scopus.com/inward/record.url?scp=84870188572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870188572&partnerID=8YFLogxK

U2 - 10.1146/annurev-genet-110711-155517

DO - 10.1146/annurev-genet-110711-155517

M3 - Review article

C2 - 22994354

AN - SCOPUS:84870188572

VL - 46

SP - 591

EP - 615

JO - Annual Review of Genetics

JF - Annual Review of Genetics

SN - 0066-4197

ER -