Understanding enzymic catalysis: The importance of short, strong hydrogen bonds

John A. Gerlt, Maurice M. Kreevoy, W. W. Cleland, Perry A. Frey

Research output: Contribution to journalReview articlepeer-review

Abstract

We have proposed previously that short, strong hydrogen bonds exist in enzyme active sites and that they are important in explaining enzymic rate enhancements. Here, we defend this proposal and provide evidence for likely changes of hydrogen bond strengths during enzymic catalysis.

Original languageEnglish (US)
Pages (from-to)259-267
Number of pages9
JournalChemistry and Biology
Volume4
Issue number4
DOIs
StatePublished - Apr 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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