Understanding enzymic catalysis: The importance of short, strong hydrogen bonds

John Alan Gerlt, Maurice M. Kreevoy, W. W. Cleland, Perry A. Frey

Research output: Contribution to journalReview article

Abstract

We have proposed previously that short, strong hydrogen bonds exist in enzyme active sites and that they are important in explaining enzymic rate enhancements. Here, we defend this proposal and provide evidence for likely changes of hydrogen bond strengths during enzymic catalysis.

Original languageEnglish (US)
Pages (from-to)259-267
Number of pages9
JournalChemistry and Biology
Volume4
Issue number4
DOIs
StatePublished - Apr 1997

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Catalysis
Hydrogen
Hydrogen bonds
Catalytic Domain
Enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Understanding enzymic catalysis : The importance of short, strong hydrogen bonds. / Gerlt, John Alan; Kreevoy, Maurice M.; Cleland, W. W.; Frey, Perry A.

In: Chemistry and Biology, Vol. 4, No. 4, 04.1997, p. 259-267.

Research output: Contribution to journalReview article

Gerlt, John Alan ; Kreevoy, Maurice M. ; Cleland, W. W. ; Frey, Perry A. / Understanding enzymic catalysis : The importance of short, strong hydrogen bonds. In: Chemistry and Biology. 1997 ; Vol. 4, No. 4. pp. 259-267.
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