Understanding enzymic catalysis: The importance of short, strong hydrogen bonds

John A. Gerlt, Maurice M. Kreevoy, W. W. Cleland, Perry A. Frey

Research output: Contribution to journalReview article


We have proposed previously that short, strong hydrogen bonds exist in enzyme active sites and that they are important in explaining enzymic rate enhancements. Here, we defend this proposal and provide evidence for likely changes of hydrogen bond strengths during enzymic catalysis.

Original languageEnglish (US)
Pages (from-to)259-267
Number of pages9
JournalChemistry and Biology
Issue number4
StatePublished - Apr 1997


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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