Abstract
Knowledge of the distributions of temperature in cardiac tissue during and after ablation is important in advancing a basic understanding of this process, and for improving its efficacy in treating arrhythmias. Technologies that enable real-time temperature detection and thermal characterization in the transmural direction can help to predict the depths and sizes of lesion that form. Herein, materials and designs for an injectable device platform that supports precision sensors of temperature and thermal transport properties distributed along the length of an ultrathin and flexible needle-type polymer substrate are introduced. The resulting system can insert into the myocardial tissue, in a minimally invasive manner, to monitor both radiofrequency ablation and cryoablation, in a manner that has no measurable effects on the natural mechanical motions of the heart. The measurement results exhibit excellent agreement with thermal simulations, thereby providing improved insights into lesion transmurality.
Original language | English (US) |
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Pages (from-to) | 373-381 |
Number of pages | 9 |
Journal | Advanced Healthcare Materials |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Feb 4 2016 |
Keywords
- Cardiac ablation monitoring
- Flexible thermal sensors
- Lesion transmurality prediction
- Thermal property detection
- Transmural thermal detection
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Pharmaceutical Science