TY - JOUR
T1 - Ultrasound-induced microbubble coalescence
AU - Postema, Michiel
AU - Marmottant, Philippe
AU - Lancée, Charles T.
AU - Hilgenfeldt, Sascha
AU - Jong, Nico De
N1 - Funding Information:
This work has been supported by the Technology Foundation STW (RKG.5104). The authors are greatly indebted to Andrea Prosperetti for many fruitful discussions on coalescence theory.
PY - 2004/10
Y1 - 2004/10
N2 - We studied the interaction of ultrasound contrast agent bubbles coated with a layer of lipids, driven by 0.5 MHz ultrasound. High-speed photography on the submicrosecond timescale reveals that some bubbles bounce off each other, while others show very fast coalescence during bubble expansion. This fast coalescence cannot be explained by dissipation-limited film drainage rates. We conclude that the lipid shell ruptures upon expansion, exposing clean free bubble interfaces that support plug flow profiles in the film and inertia-limited drainage whose time scales match those of the observed coalescence. (E-mail: [email protected])
AB - We studied the interaction of ultrasound contrast agent bubbles coated with a layer of lipids, driven by 0.5 MHz ultrasound. High-speed photography on the submicrosecond timescale reveals that some bubbles bounce off each other, while others show very fast coalescence during bubble expansion. This fast coalescence cannot be explained by dissipation-limited film drainage rates. We conclude that the lipid shell ruptures upon expansion, exposing clean free bubble interfaces that support plug flow profiles in the film and inertia-limited drainage whose time scales match those of the observed coalescence. (E-mail: [email protected])
KW - Film drainage
KW - Microbubble coalescence
KW - Ultrasound contrast agent
KW - high-speed photography
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U2 - 10.1016/j.ultrasmedbio.2004.08.008
DO - 10.1016/j.ultrasmedbio.2004.08.008
M3 - Article
C2 - 15582233
AN - SCOPUS:9644274263
SN - 0301-5629
VL - 30
SP - 1337
EP - 1344
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 10
ER -