Ultrasound-induced microbubble coalescence

Michiel Postema, Philippe Marmottant, Charles T. Lancée, Sascha Hilgenfeldt, Nico De Jong

Research output: Contribution to journalArticle

Abstract

We studied the interaction of ultrasound contrast agent bubbles coated with a layer of lipids, driven by 0.5 MHz ultrasound. High-speed photography on the submicrosecond timescale reveals that some bubbles bounce off each other, while others show very fast coalescence during bubble expansion. This fast coalescence cannot be explained by dissipation-limited film drainage rates. We conclude that the lipid shell ruptures upon expansion, exposing clean free bubble interfaces that support plug flow profiles in the film and inertia-limited drainage whose time scales match those of the observed coalescence. (E-mail: M.postema@erasmusmc.nl)

Original languageEnglish (US)
Pages (from-to)1337-1344
Number of pages8
JournalUltrasound in Medicine and Biology
Volume30
Issue number10
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

Fingerprint

Microbubbles
coalescing
Drainage
bubbles
Lipids
Photography
drainage
Contrast Media
lipids
Rupture
high speed photography
expansion
plugs
inertia
dissipation
profiles
interactions

Keywords

  • Film drainage
  • Microbubble coalescence
  • Ultrasound contrast agent
  • high-speed photography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

Cite this

Ultrasound-induced microbubble coalescence. / Postema, Michiel; Marmottant, Philippe; Lancée, Charles T.; Hilgenfeldt, Sascha; Jong, Nico De.

In: Ultrasound in Medicine and Biology, Vol. 30, No. 10, 01.10.2004, p. 1337-1344.

Research output: Contribution to journalArticle

Postema, Michiel ; Marmottant, Philippe ; Lancée, Charles T. ; Hilgenfeldt, Sascha ; Jong, Nico De. / Ultrasound-induced microbubble coalescence. In: Ultrasound in Medicine and Biology. 2004 ; Vol. 30, No. 10. pp. 1337-1344.
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