Ultrasound characterization of three animal mammary tumors from three-dimensional acoustic tissue models

Jonathan Mamou, Michael L. Oelze, William D. O'Brien, James F. Zachary

Research output: Chapter in Book/Report/Conference proceedingConference contribution


With very few exceptions, the tissue microstructures responsible for ultrasonic scattering remain unidentified. Identification of these structures would lead to potentially improved methodologies for characterizing tissue and diagnosing disease from ultrasonic backscatter measurements. Three-dimensional (3D) acoustic models of tissue microstructure, termed 3D impedance maps (3DZMs) were obtained for three tumors (a rat fibroadenoma, a mouse carcinoma, and a mouse sarcoma). 3DZMs were inferred from a 3D histological data set of tissue, and are independent of ultrasonically acquired data. The Fourier transform of the 3D spatial autocorrelation of the 3DZM was used to estimate the backscattered power spectrum. Spectral estimates (scatterer size and acoustic concentration) were then obtained by fitting an assumed scattering model (form factor, FF) to the power spectrum. At first, a Gaussian FF was used to allow comparison with the independent in vivo measurements from the same three tumor tissues. Then, a tissue-specific FF was deduced from each 3DZM. The 3DZM estimates using the Gaussian FF led to scatterer estimates very similar (within 10%) to those obtained with the independent ultrasonic backscatter measurements. However, a clear distinction could not be made between the sarcoma and carcinoma using the estimates obtained with the Gaussian FF. Statistical distinction was finally obtained when the 3DZM-deduced FF was used to obtain estimates. Thus, 3DZMs are unique computational phantoms that can to help identify ultrasonic scattering sites, and to develop advanced models and sensitive ultrasonic techniques to diagnose disease.

Original languageEnglish (US)
Title of host publication2005 IEEE Ultrasonics Symposium
Number of pages4
StatePublished - 2005
Event2005 IEEE Ultrasonics Symposium - Rotterdam, Netherlands
Duration: Sep 18 2005Sep 21 2005

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117


Other2005 IEEE Ultrasonics Symposium

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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