Ultrasound-based imaging of nanoparticles: From molecular and cellular imaging to therapy guidance

S. Mallidi, B. Wang, M. Mehrmohammadi, M. Qu, Y. S. Chen, P. Joshi, S. Kim, K. A. Homan, A. B. Karpiouk, R. W. Smalling, K. Sokolov, S. Y. Emelianov

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The effectiveness of an imaging technique is often based on the ability to image quantitatively both morphological and physiological functions of the tissue. Here we present several ultrasound-based imaging techniques capable of visualizing both structural and functional properties of living tissue. Each imaging system utilizes custom-made, targeted nanoparticles developed to probe specific molecular events. Therefore, images of these nanoparticles display molecular processes in the body. Furthermore, the developed nanoparticle contrast agents can also be used for image-guided molecular therapy. For each imaging system, the basic physics and principles behind each approach are described. Experimental aspects of each imaging system including fabrication of integrated imaging probes and associated imaging hardware, and design of targeted contrast agents are discussed. Finally, biomedical and clinical applications of the developed imaging approaches ranging from microscopic to macroscopic imaging of cardiovascular diseases, cancer detection, diagnosis, therapy and therapy monitoring are demonstrated and discussed.

Original languageEnglish (US)
Title of host publication2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
StatePublished - 2009
Externally publishedYes
Event2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy
Duration: Sep 20 2009Sep 23 2009

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117


Other2009 IEEE International Ultrasonics Symposium, IUS 2009


  • Contrast agents
  • Image guidance
  • Magneto-motive ultrasound
  • Molecular imaging
  • Monitoring
  • Multi-modality imaging
  • Nanoparticles
  • Photoacoustics
  • Therapy
  • Ultrasound

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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