Abstract
This chapter summarizes the approaches to tissue elasticity imaging based on ultrasonic and/or optical modalities that have been developed during the last three decades. We describe a wide range of techniques, from simply mapping soft-tissue stiffness to accurately estimating a complex modulus of viscoelastic tissues, in vivo. We describe how experimental parameters determine the spatiotemporal properties of the force that then couple to the properties of the imaging system used to track deformations and to specific tissue geometries. These experimental-design parameters determine the resolution and noise properties of the image, and they can also be set to select which elements of tissue structure contribute to the object contrast. Parameter selection depends on measurement goals, which might include anything from a basic-science investigation into mechanobiology of disease processes to diagnosis of focal diseases in a patient. Although there are many coupled parameters to consider, they provide a broad pallet of opportunities for discovery and diagnosis related to changes in the mechanical properties of tissues.
| Original language | English (US) |
|---|---|
| Title of host publication | Handbook of Imaging in Biological Mechanics |
| Publisher | CRC Press |
| Pages | 83-96 |
| Number of pages | 14 |
| ISBN (Electronic) | 9781466588141 |
| ISBN (Print) | 9781466588134 |
| DOIs | |
| State | Published - Jan 1 2014 |
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ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Engineering(all)
- Physics and Astronomy(all)
Cite this
Ultrasound and optical methods for dynamic viscoelastic imaging. / Wang, Yue; Adie, Steven G.; Boppart, Stephen Allen; Insana, Michael.
Handbook of Imaging in Biological Mechanics. CRC Press, 2014. p. 83-96.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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TY - CHAP
T1 - Ultrasound and optical methods for dynamic viscoelastic imaging
AU - Wang, Yue
AU - Adie, Steven G.
AU - Boppart, Stephen Allen
AU - Insana, Michael
PY - 2014/1/1
Y1 - 2014/1/1
N2 - This chapter summarizes the approaches to tissue elasticity imaging based on ultrasonic and/or optical modalities that have been developed during the last three decades. We describe a wide range of techniques, from simply mapping soft-tissue stiffness to accurately estimating a complex modulus of viscoelastic tissues, in vivo. We describe how experimental parameters determine the spatiotemporal properties of the force that then couple to the properties of the imaging system used to track deformations and to specific tissue geometries. These experimental-design parameters determine the resolution and noise properties of the image, and they can also be set to select which elements of tissue structure contribute to the object contrast. Parameter selection depends on measurement goals, which might include anything from a basic-science investigation into mechanobiology of disease processes to diagnosis of focal diseases in a patient. Although there are many coupled parameters to consider, they provide a broad pallet of opportunities for discovery and diagnosis related to changes in the mechanical properties of tissues.
AB - This chapter summarizes the approaches to tissue elasticity imaging based on ultrasonic and/or optical modalities that have been developed during the last three decades. We describe a wide range of techniques, from simply mapping soft-tissue stiffness to accurately estimating a complex modulus of viscoelastic tissues, in vivo. We describe how experimental parameters determine the spatiotemporal properties of the force that then couple to the properties of the imaging system used to track deformations and to specific tissue geometries. These experimental-design parameters determine the resolution and noise properties of the image, and they can also be set to select which elements of tissue structure contribute to the object contrast. Parameter selection depends on measurement goals, which might include anything from a basic-science investigation into mechanobiology of disease processes to diagnosis of focal diseases in a patient. Although there are many coupled parameters to consider, they provide a broad pallet of opportunities for discovery and diagnosis related to changes in the mechanical properties of tissues.
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U2 - 10.1201/b17566
DO - 10.1201/b17566
M3 - Chapter
AN - SCOPUS:84981351541
SN - 9781466588134
SP - 83
EP - 96
BT - Handbook of Imaging in Biological Mechanics
PB - CRC Press
ER -