Ultrahigh sensitivity nanoplasmonic resonance energy transfer spectroscopic biomolecular imaging

G. Logan Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanoplasmonic resonance spectroscopy enhances sensitivity and throughput of conventional SPR detection technique while still suffers with modest molecular specificity. Here we demonstrated a new sensing technique 0- nano plasmonic resonance energy transfer (PRET) spectroscopy to detect complex biomolecular activities including conformational change, electron transfer and protein interactions with ultrahigh sensitivity and specificity. Compared to FRET sensing technology, PRET has much stronger optical signal to noise ratio and minimal photobleaching problems. Nano PRET spectroscopic molecular imaging technique can be used in multiplexed label-free cancer biomarker detections and environmental sensing applications.

Original languageEnglish (US)
Title of host publicationAdvanced Environmental, Chemical, and Biological Sensing Technologies VI
DOIs
StatePublished - Sep 8 2009
EventAdvanced Environmental, Chemical, and Biological Sensing Technologies VI - Orlando, FL, United States
Duration: Apr 13 2009Apr 14 2009

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume7312
ISSN (Print)0277-786X

Other

OtherAdvanced Environmental, Chemical, and Biological Sensing Technologies VI
CountryUnited States
CityOrlando, FL
Period4/13/094/14/09

Keywords

  • Molecular imaging
  • Plasmonics
  • Resonance energy transfer
  • Spectroscopy

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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  • Cite this

    Liu, G. L. (2009). Ultrahigh sensitivity nanoplasmonic resonance energy transfer spectroscopic biomolecular imaging. In Advanced Environmental, Chemical, and Biological Sensing Technologies VI [731204] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 7312). https://doi.org/10.1117/12.819052