Ultra-compact, high sensitivity label-free biosensor using VCSEL

Carlos F.R. Mateus, Michael C.Y. Huang, Jonathan Foley, P. Robert Bearty, Peter Li, Brian T. Cunningham, Connie J. Chang-Hasnain

Research output: Contribution to journalConference articlepeer-review


We report a label-free, highly sensitive biosensor using a vertical cavity surface emitting laser (VCSEL) based measurement system for the detection and monitoring of biomolecular interactions. The sensor system consists of a VCSEL, a plastic guided mode resonant (GMR) filter, and two pin detectors. The system has several advantages such as extreme compactness, high sensitivity, high throughput, fest measurements, low power consumption, low cost, and the potential to become portable. Experimentally, the biosensor system has shown to be highly sensitive to the surface modifications due to molecular bindings, with the ability to detect the thickness variations <10Å and retractive index variations <0.005. The biosensor also has demonstrated its high sensitivity for the detection of antibody-antigen proteins bindings, with the mouse IgG concentration as low as lpg/ml (6.7 femto-Molar), and its ability for measuring both static and dynamic interactions among proteins.

Original languageEnglish (US)
Pages (from-to)140-146
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2004
Externally publishedYes
EventMicroarrays and Combinatorial Techniques: Design, Fabrication, and Analysis II - San Jose, CA, United States
Duration: Jan 25 2004Jan 26 2004


  • Biomedical Transducer
  • Drugs
  • Dynamic Response
  • Label-free
  • Non-intrusive
  • Protein

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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