Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice

Uwe Rudolph, Milton J. Finegold, Susan S. Rich, Gregory R. Harriman, Yogambal Srinivasan, Philippe Brabet, Guylain Boulay, Allan Bradley, Lutz Birnbaumer

Research output: Contribution to journalArticlepeer-review


G proteins are involved in cellular signalling and regulate a variety of biological processes including differentiation and development. We have generated mice deficient for the G protein subunit αi2 (Gαi2) by homologous recombination in embryonic stem cells. Gαi2–deficient mice display growth retardation and develop a lethal diffuse colitis with clinical and histopathological features closely resembling ulcerative colitis in humans, including the development of adenocarcinoma of the colon. Prior to clinical symptoms, the mice show profound alterations in thymocyte maturation and function. The study of these animals should provide important insights into the pathogenesis of ulcerative colitis as well as carcinogenesis.

Original languageEnglish (US)
Pages (from-to)143-150
Number of pages8
JournalNature Genetics
Issue number2
StatePublished - Jun 1995
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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