Ubiquitin proteasome system-mediated degradation of synaptic proteins: An update from the postsynaptic side

Research output: Contribution to journalReview articlepeer-review

Abstract

The ubiquitin proteasome system is one of the principle mechanisms for the regulation of protein homeostasis in mammalian cells. In dynamic cellular structures such as neuronal synapses, ubiquitin proteasome system and protein translation provide an efficient way for cells to respond promptly to local stimulation and regulate neuroplasticity. The majority of research related to long-term plasticity has been focused on the postsynapses and has shown that ubiquitination and subsequent degradation of specific proteins are involved in various activity-dependent plasticity events. This review summarizes recent achievements in understanding ubiquitination of postsynaptic proteins and its impact on synapse plasticity and discusses the direction for advancing future research in the field.

Original languageEnglish (US)
Pages (from-to)2838-2842
Number of pages5
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1843
Issue number12
DOIs
StatePublished - Aug 16 2014

Keywords

  • E3 ligase
  • Neuronal activity
  • Plasticity
  • Proteasome
  • Synapse
  • Ubiquitination

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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