TY - JOUR
T1 - Tyrosine hydroxylase positive neurons and their contacts with vasoactive intestinal polypeptide-containing fibers in the hypothalamus of the diurnal murid rodent, Arvicanthis niloticus
AU - Mahoney, Megan M.
AU - Ramanathan, Chidambaram
AU - Smale, Laura
N1 - Funding Information:
We are grateful to Anna Baumgras and Nicole Timm for their technical assistance and to Kaliris Salas-Ramirez and Gladys Martinez for help with the immunocytochemistry. This research was supported by grants from the National Science Foundation (IBN-0130977 to L.S. Smale) and the National Institute of Mental Health (T32 HD07048 to M.M. Mahoney).
PY - 2007/5
Y1 - 2007/5
N2 - Diurnal and nocturnal animals differ with respect to the timing of a host of behavioral and physiological events including those associated with neuroendocrine functions, but the neural bases of these differences are poorly understood. In nocturnal species, rhythms in tyrosine hydroxylase-containing (TH+) neurons in the hypothalamus appear to be responsible for rhythms in prolactin secretion. Here we investigated TH+ cells in a diurnal rodent (Arvicanthis niloticus, the unstriped Nile grass rat), and comparing them with those of a nocturnal rodent (Rattus norvegicus, Sprague-Dawley rat). We also examined relationships between TH+ cells and fibers containing vasoactive intestinal polypeptide (VIP) that are thought to originate from cells in the suprachiasmatic nucleus (SCN), the site of the primary circadian clock in mammals. The distribution of TH+ neurons was very similar in the two species except for a population of cells in the basal forebrain that was only present in grass rats. Fibers containing VIP appeared to contact neuroendocrine TH+ cells in both species. These data suggest that, though there may be subtle species differences, temporal information is likely to be carried along the same direct pathways from the SCN to the TH+ neurons in day- and night-active species.
AB - Diurnal and nocturnal animals differ with respect to the timing of a host of behavioral and physiological events including those associated with neuroendocrine functions, but the neural bases of these differences are poorly understood. In nocturnal species, rhythms in tyrosine hydroxylase-containing (TH+) neurons in the hypothalamus appear to be responsible for rhythms in prolactin secretion. Here we investigated TH+ cells in a diurnal rodent (Arvicanthis niloticus, the unstriped Nile grass rat), and comparing them with those of a nocturnal rodent (Rattus norvegicus, Sprague-Dawley rat). We also examined relationships between TH+ cells and fibers containing vasoactive intestinal polypeptide (VIP) that are thought to originate from cells in the suprachiasmatic nucleus (SCN), the site of the primary circadian clock in mammals. The distribution of TH+ neurons was very similar in the two species except for a population of cells in the basal forebrain that was only present in grass rats. Fibers containing VIP appeared to contact neuroendocrine TH+ cells in both species. These data suggest that, though there may be subtle species differences, temporal information is likely to be carried along the same direct pathways from the SCN to the TH+ neurons in day- and night-active species.
KW - Arvicanthis
KW - Circadian
KW - Diurnal
KW - Dopamine
KW - Suprachiasmatic nucleus
KW - Tuberohypophyseal
KW - Tuberoinfundibular
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UR - http://www.scopus.com/inward/citedby.url?scp=34047178493&partnerID=8YFLogxK
U2 - 10.1016/j.jchemneu.2007.02.001
DO - 10.1016/j.jchemneu.2007.02.001
M3 - Article
C2 - 17368836
AN - SCOPUS:34047178493
SN - 0891-0618
VL - 33
SP - 131
EP - 139
JO - Journal of Chemical Neuroanatomy
JF - Journal of Chemical Neuroanatomy
IS - 3
ER -