TY - JOUR
T1 - Two new l-serine variants of microcystins-LR and -RR from Anabaena sp. strains 202 A1 and 202 A2
AU - Namikoshi, Michio
AU - Sivonen, Kaarina
AU - Evans, William R.
AU - Carmichael, Wayne W.
AU - Sun, Furong
AU - Rouhiainen, Leo
AU - Luukkainen, Raija
AU - Rinehart, Kenneth L.
N1 - Funding Information:
Acknowledgement.-This study was supported in part by grants from the National Institutes of Allergy and Infectious Diseases (AI 04769) and of General Medical Sciences (GM 27029) to K .L.R. and by a subcontract from the former grant to W.W.C . Research at the University of Helsinki was supported by grants from the Academy of Finland, the Maj and Tor Nessling Foundation, and University of Helsinki.
PY - 1992/11
Y1 - 1992/11
N2 - Two new microcystins, [l-Ser7]microcystin-LR (1) and [l-Ser7]microcystin-RR (2), were isolated from a filamentous fresh water cyanobacterium (blue-green alga), Anabaena sp. strain 202 A1, along with the two major toxins, [Dha7]microcystin-LR (3) and [Dha7]microcystin-RR (4) and their minor components the d-Asp variants [d-Asp3,Dha7]microcystin-LR (5) and [d-Asp3,Dha7]microcystin-RR (6). Anabaena sp. strain 202 A1 also produced another new toxin, whose structure is tentatively proposed as [d-Asp3,l-Ser7]microcystin-XR (7), where X is a leucine homologue. Anabaena sp. strain 202 A2 produced one new microcystin, 1, and three known microcystins, 3, 4, and 5. The structures of the toxins were assigned based on their amino acid analyses, and fast atom bombardment mass spectrometry data.
AB - Two new microcystins, [l-Ser7]microcystin-LR (1) and [l-Ser7]microcystin-RR (2), were isolated from a filamentous fresh water cyanobacterium (blue-green alga), Anabaena sp. strain 202 A1, along with the two major toxins, [Dha7]microcystin-LR (3) and [Dha7]microcystin-RR (4) and their minor components the d-Asp variants [d-Asp3,Dha7]microcystin-LR (5) and [d-Asp3,Dha7]microcystin-RR (6). Anabaena sp. strain 202 A1 also produced another new toxin, whose structure is tentatively proposed as [d-Asp3,l-Ser7]microcystin-XR (7), where X is a leucine homologue. Anabaena sp. strain 202 A2 produced one new microcystin, 1, and three known microcystins, 3, 4, and 5. The structures of the toxins were assigned based on their amino acid analyses, and fast atom bombardment mass spectrometry data.
UR - http://www.scopus.com/inward/record.url?scp=0026442485&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026442485&partnerID=8YFLogxK
U2 - 10.1016/0041-0101(92)90521-6
DO - 10.1016/0041-0101(92)90521-6
M3 - Article
C2 - 1485340
AN - SCOPUS:0026442485
SN - 0041-0101
VL - 30
SP - 1457
EP - 1464
JO - Toxicon
JF - Toxicon
IS - 11
ER -