Two new l-serine variants of microcystins-LR and -RR from Anabaena sp. strains 202 A1 and 202 A2

Michio Namikoshi, Kaarina Sivonen, William R. Evans, Wayne W. Carmichael, Furong Sun, Leo Rouhiainen, Raija Luukkainen, Kenneth L. Rinehart

Research output: Contribution to journalArticle

Abstract

Two new microcystins, [l-Ser7]microcystin-LR (1) and [l-Ser7]microcystin-RR (2), were isolated from a filamentous fresh water cyanobacterium (blue-green alga), Anabaena sp. strain 202 A1, along with the two major toxins, [Dha7]microcystin-LR (3) and [Dha7]microcystin-RR (4) and their minor components the d-Asp variants [d-Asp3,Dha7]microcystin-LR (5) and [d-Asp3,Dha7]microcystin-RR (6). Anabaena sp. strain 202 A1 also produced another new toxin, whose structure is tentatively proposed as [d-Asp3,l-Ser7]microcystin-XR (7), where X is a leucine homologue. Anabaena sp. strain 202 A2 produced one new microcystin, 1, and three known microcystins, 3, 4, and 5. The structures of the toxins were assigned based on their amino acid analyses, and fast atom bombardment mass spectrometry data.

Original languageEnglish (US)
Pages (from-to)1457-1464
Number of pages8
JournalToxicon
Volume30
Issue number11
DOIs
StatePublished - Nov 1992

ASJC Scopus subject areas

  • Toxicology

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