In recent studies, two distinct mechanisms have been proposed to account for major histocompatibility complex (MHC) restriction of T-cell activity: (a) evolution-driven interactions between T-cell receptor (TCR) variable regions and MHC, and (b) a requirement for CD4 or CD8 binding to MHC to initiate signalling through the TCR complex. Both mechanisms are likely to be essential, but for different reasons.
- CDR, complementarity determining region
- V, variable
- TCR, T-cell receptor
- pepMHC, peptide complexed with an MHC product;
- MHC, major histocompatibility complex
- Lck, lymphocyte-specific tyrosine kinase
- EBV, Epstein-Barr virus