TY - JOUR
T1 - Two-layer multiplexed peristaltic pumps for high-density integrated microfluidics
AU - Cole, Matthew C.
AU - Desai, Amit V.
AU - Kenis, Paul J.A.
N1 - Funding Information:
We gratefully acknowledge financial support from the National Science Foundation under awards CMMI 03-28162 and CMMI 07-49028 to Nano-CEMMS; a NanoScience & Engineering Center (NSEC) on Nanomanufacturing. We also acknowledge the financial support from the Department of Energy (DOE) through the National Institute for NanoEngineering (NINE) initiative of the Lab Directed Research and Development (LDRD) program at Sandia National Laboratories. Profilometry was carried out in the Frederick Seitz Materials Research Laboratory Central Facilities, University of Illinois, which is supported in part by the U.S. Department of Energy under grants DE-FG02-07ER46453 and DE-FG02-07ER46471 .
PY - 2011/1/28
Y1 - 2011/1/28
N2 - The integration and operation of a large number of components is needed to enable ever more complex and integrated chemical and biological processes on a single microfluidic chip. The capabilities of these chips are often limited by the maximum number of pumps and valves that can be controlled on a single chip, a limitation typically set by the number of pneumatic interconnects available from ancillary hardware. Here, we report a multiplexing approach that greatly reduces the number of external pneumatic connections needed for the operation of a large number of peristaltic pumps. The utility of the approach is demonstrated with a complex microfluidic network capable of generating and routing liquid droplets in a two-phase flow. We also report a set of design rules for the design and operation of multiplexed peristaltic pumps, based on a study of the effect of the number of valves per pump and the valve-to-valve distance on the performance of peristaltic pumps. The multiplexing approach reported here may find application in a wide range of microfluidic chips for chemical and biological applications, especially those that require the integration of many different operations on a single chip and those that need to perform similar operations massively in parallel, in sub-nanoliter volumes.
AB - The integration and operation of a large number of components is needed to enable ever more complex and integrated chemical and biological processes on a single microfluidic chip. The capabilities of these chips are often limited by the maximum number of pumps and valves that can be controlled on a single chip, a limitation typically set by the number of pneumatic interconnects available from ancillary hardware. Here, we report a multiplexing approach that greatly reduces the number of external pneumatic connections needed for the operation of a large number of peristaltic pumps. The utility of the approach is demonstrated with a complex microfluidic network capable of generating and routing liquid droplets in a two-phase flow. We also report a set of design rules for the design and operation of multiplexed peristaltic pumps, based on a study of the effect of the number of valves per pump and the valve-to-valve distance on the performance of peristaltic pumps. The multiplexing approach reported here may find application in a wide range of microfluidic chips for chemical and biological applications, especially those that require the integration of many different operations on a single chip and those that need to perform similar operations massively in parallel, in sub-nanoliter volumes.
KW - Microfluidic multiplexing
KW - Multilayer soft lithography
KW - Pneumatic valves and pumps
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U2 - 10.1016/j.snb.2010.07.012
DO - 10.1016/j.snb.2010.07.012
M3 - Article
AN - SCOPUS:78751591576
SN - 0925-4005
VL - 151
SP - 384
EP - 393
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
IS - 2
ER -