Two component Bacillus lantibiotic and methods for producing and using the same

Wilfred A van der Donk; Amanda L. McClerren; Lisa E. Cooper

Two component Bacillus lantibiotic and methods for producing and using the same

Wilfred A van der Donk (Inventor), Amanda L. McClerren (Inventor), Lisa E. Cooper (Inventor)

Research output: Patent

Abstract

The present invention relates to two-component lantibiotics isolated from Bacillus sp. Methods for producing said lantibiotics are provided, wherein dehydration and cyclization of the peptides is carried out by two substrate-specific modifying enzymes. Given the antimicrobial activity of the instant lantibiotics, methods for preventing or treating bacterial infections are also provided.

Original language	English (US)
U.S. patent number	7985837
Filing date	10/31/07
State	Published - Jul 26 2011

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title = "Two component Bacillus lantibiotic and methods for producing and using the same",

abstract = "The present invention relates to two-component lantibiotics isolated from Bacillus sp. Methods for producing said lantibiotics are provided, wherein dehydration and cyclization of the peptides is carried out by two substrate-specific modifying enzymes. Given the antimicrobial activity of the instant lantibiotics, methods for preventing or treating bacterial infections are also provided.",

author = "{van der Donk}, {Wilfred A} and McClerren, {Amanda L.} and Cooper, {Lisa E.}",

note = "INTRODUCTION This invention was made in the course of research sponsored by the National Institutes of Health, grant number GM 58822. The government has certain rights in the invention.; 7985837",

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T1 - Two component Bacillus lantibiotic and methods for producing and using the same

AU - van der Donk, Wilfred A

AU - McClerren, Amanda L.

AU - Cooper, Lisa E.

N1 - INTRODUCTION This invention was made in the course of research sponsored by the National Institutes of Health, grant number GM 58822. The government has certain rights in the invention.

PY - 2011/7/26

Y1 - 2011/7/26

N2 - The present invention relates to two-component lantibiotics isolated from Bacillus sp. Methods for producing said lantibiotics are provided, wherein dehydration and cyclization of the peptides is carried out by two substrate-specific modifying enzymes. Given the antimicrobial activity of the instant lantibiotics, methods for preventing or treating bacterial infections are also provided.

AB - The present invention relates to two-component lantibiotics isolated from Bacillus sp. Methods for producing said lantibiotics are provided, wherein dehydration and cyclization of the peptides is carried out by two substrate-specific modifying enzymes. Given the antimicrobial activity of the instant lantibiotics, methods for preventing or treating bacterial infections are also provided.

M3 - Patent

M1 - 7985837

Y2 - 2007/10/31

ER -

Two component Bacillus lantibiotic and methods for producing and using the same

Abstract

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