Turn-on fluorescent sensors for Cu-rich amyloid β peptide aggregates

Yiran Huang, Liang Sun, Liviu M. Mirica

Research output: Contribution to journalArticlepeer-review


Protein misfolding and metal dishomeostasis are two key pathological factors of Alzheimer's disease. Previous studies have shown that Cu-mediated amyloid β (Aβ) peptide aggregation leads to the formation of neurotoxic Aβ oligomers. Herein, we report a series of picolinic acid-based Cu-activatable sensors, which can be used for the fluorescence imaging of Cu-rich Aβ aggregates.
Original languageEnglish (US)
Pages (from-to)709-713
JournalSensors & Diagnostics
Issue number4
StatePublished - May 9 2022


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