Tunnel engineering enables multifaceted improvements in halogenase

Zhengyi Zhang; Huimin Zhao

doi:10.1016/j.checat.2022.09.010

Tunnel engineering enables multifaceted improvements in halogenase

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In a recent article in Nature Catalysis, Prakinee et al. applied a mechanism-guided protein-engineering strategy to optimize the behaviors of a flavin-dependent halogenase by tuning the hydrophobic interactions within the tunnel for hypohalous acid (HOX) transport. This strategy allows the control of the fate of enzymatic intermediates at low cost.

Original language	English (US)
Pages (from-to)	2432-2434
Number of pages	3
Journal	Chem Catalysis
Volume	2
Issue number	10
DOIs	https://doi.org/10.1016/j.checat.2022.09.010
State	Published - Oct 20 2022

ASJC Scopus subject areas

Chemistry (miscellaneous)
Physical and Theoretical Chemistry
Organic Chemistry

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10.1016/j.checat.2022.09.010

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title = "Tunnel engineering enables multifaceted improvements in halogenase",

abstract = "In a recent article in Nature Catalysis, Prakinee et al. applied a mechanism-guided protein-engineering strategy to optimize the behaviors of a flavin-dependent halogenase by tuning the hydrophobic interactions within the tunnel for hypohalous acid (HOX) transport. This strategy allows the control of the fate of enzymatic intermediates at low cost.",

author = "Zhengyi Zhang and Huimin Zhao",

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AB - In a recent article in Nature Catalysis, Prakinee et al. applied a mechanism-guided protein-engineering strategy to optimize the behaviors of a flavin-dependent halogenase by tuning the hydrophobic interactions within the tunnel for hypohalous acid (HOX) transport. This strategy allows the control of the fate of enzymatic intermediates at low cost.

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Tunnel engineering enables multifaceted improvements in halogenase

Abstract

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