In a recent article in Nature Catalysis, Prakinee et al. applied a mechanism-guided protein-engineering strategy to optimize the behaviors of a flavin-dependent halogenase by tuning the hydrophobic interactions within the tunnel for hypohalous acid (HOX) transport. This strategy allows the control of the fate of enzymatic intermediates at low cost.
ASJC Scopus subject areas
- Chemistry (miscellaneous)
- Physical and Theoretical Chemistry
- Organic Chemistry