Tunnel engineering enables multifaceted improvements in halogenase

Zhengyi Zhang, Huimin Zhao

Research output: Contribution to journalComment/debatepeer-review


In a recent article in Nature Catalysis, Prakinee et al. applied a mechanism-guided protein-engineering strategy to optimize the behaviors of a flavin-dependent halogenase by tuning the hydrophobic interactions within the tunnel for hypohalous acid (HOX) transport. This strategy allows the control of the fate of enzymatic intermediates at low cost.

Original languageEnglish (US)
Pages (from-to)2432-2434
Number of pages3
JournalChem Catalysis
Issue number10
StatePublished - Oct 20 2022

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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