Tuning responsiveness and structural integrity of a pH responsive hydrogel using a poly(ethylene glycol) cross-linker

Jae Hyun Jeong, John J. Schmidt, Chaenyung Cha, Hyunjoon Kong

Research output: Contribution to journalArticlepeer-review


Stimulus responsive hydrogels have received considerable attention due to their ability to exhibit reversible volumetric changes in response to external stimuli. The shrinkage or expansion of a hydrogel often results in irreversible structural failure, but limited efforts have been made to resolve the challenge of hydrogel fracture. This study presents that the number (FM) of cross-linkers and the molecular weight (Mw) of the cross-linkers play critical roles determining the responsiveness and the structural integrity of a hydrogel exposed to external stimuli. A pH-responsive hydrogel was prepared by cross-linking poly(acrylamide-co-acrylic acid) with bis-acrylamide (Bis) or poly(ethylene glycol) diacrylate (PEGDA) of varying Mw. The deswelling rate of the hydrogel incubated in an acidic medium was solely controlled by the number of elastically effective cross-links (N) which was increased with FM and Mw of the cross-linker. The structural integrity of the hydrogel during a volumetric change was dependent on the work to fracture and the deswelling rate, which was tuned with the M w of the cross-linker. These critical roles of cross-linkers in mediating the elastic response and the structural integrity of the hydrogel were further related to the ability of cross-linkers of different Mw to self-organize. Ultimately, the results of this study will be highly useful to tuning performance of a wide array of stimulus responsive hydrogels.

Original languageEnglish (US)
Pages (from-to)3930-3938
Number of pages9
JournalSoft Matter
Issue number16
StatePublished - Aug 21 2010

ASJC Scopus subject areas

  • General Chemistry
  • Condensed Matter Physics


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