Tunable Luminescent Carbon Nanospheres with Well-Defined Nanoscale Chemistry for Synchronized Imaging and Therapy

Prabuddha Mukherjee, Santosh K. Misra, Mark C. Gryka, Huei Huei Chang, Saumya Tiwari, William L. Wilson, John W. Scott, Rohit Bhargava, Dipanjan Pan

Research output: Contribution to journalArticle

Abstract

In this work, we demonstrate the significance of defined surface chemistry in synthesizing luminescent carbon nanomaterials (LCN) with the capability to perform dual functions (i.e., diagnostic imaging and therapy). The surface chemistry of LCN has been tailored to achieve two different varieties: one that has a thermoresponsive polymer and aids in the controlled delivery of drugs, and the other that has fluorescence emission both in the visible and near-infrared (NIR) region and can be explored for advanced diagnostic modes. Although these particles are synthesized using simple, yet scalable hydrothermal methods, they exhibit remarkable stability, photoluminescence and biocompatibility. The photoluminescence properties of these materials are tunable through careful choice of surface-passivating agents and can be exploited for both visible and NIR imaging. Here the synthetic strategy demonstrates the possibility to incorporate a potent antimetastatic agent for inhibiting melanomas in vitro. Since both particles are Raman active, their dispersion on skin surface is reported with Raman imaging and utilizing photoluminescence, their depth penetration is analysed using fluorescence 3D imaging. Our results indicate a new generation of tunable carbon-based probes for diagnosis, therapy or both.

Original languageEnglish (US)
Pages (from-to)4691-4703
Number of pages13
JournalSmall
Volume11
Issue number36
DOIs
StatePublished - Sep 1 2015

Fingerprint

Nanospheres
Photoluminescence
Carbon
Nanostructures
Surface chemistry
Imaging techniques
Nanostructured materials
Fluorescence
Optical Imaging
Infrared imaging
Diagnostic Imaging
Biocompatibility
Melanoma
Skin
Polymers
Therapeutics
Infrared radiation
Pharmaceutical Preparations

Keywords

  • Raman imaging
  • anticancer drugs
  • carbon nanoparticles
  • nanomedicine
  • skin cancers
  • theranostics

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Cite this

Mukherjee, P., Misra, S. K., Gryka, M. C., Chang, H. H., Tiwari, S., Wilson, W. L., ... Pan, D. (2015). Tunable Luminescent Carbon Nanospheres with Well-Defined Nanoscale Chemistry for Synchronized Imaging and Therapy. Small, 11(36), 4691-4703. https://doi.org/10.1002/smll.201500728

Tunable Luminescent Carbon Nanospheres with Well-Defined Nanoscale Chemistry for Synchronized Imaging and Therapy. / Mukherjee, Prabuddha; Misra, Santosh K.; Gryka, Mark C.; Chang, Huei Huei; Tiwari, Saumya; Wilson, William L.; Scott, John W.; Bhargava, Rohit; Pan, Dipanjan.

In: Small, Vol. 11, No. 36, 01.09.2015, p. 4691-4703.

Research output: Contribution to journalArticle

Mukherjee, P, Misra, SK, Gryka, MC, Chang, HH, Tiwari, S, Wilson, WL, Scott, JW, Bhargava, R & Pan, D 2015, 'Tunable Luminescent Carbon Nanospheres with Well-Defined Nanoscale Chemistry for Synchronized Imaging and Therapy', Small, vol. 11, no. 36, pp. 4691-4703. https://doi.org/10.1002/smll.201500728
Mukherjee, Prabuddha ; Misra, Santosh K. ; Gryka, Mark C. ; Chang, Huei Huei ; Tiwari, Saumya ; Wilson, William L. ; Scott, John W. ; Bhargava, Rohit ; Pan, Dipanjan. / Tunable Luminescent Carbon Nanospheres with Well-Defined Nanoscale Chemistry for Synchronized Imaging and Therapy. In: Small. 2015 ; Vol. 11, No. 36. pp. 4691-4703.
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