Tunable graphene quantum point contact transistor for DNA detection and characterization

Anuj Girdhar, Chaitanya Sathe, Klaus Schulten, Jean Pierre Leburton

Research output: Contribution to journalArticlepeer-review


A graphene membrane conductor containing a nanopore in a quantum point contact geometry is a promising candidate to sense, and potentially sequence, DNA molecules translocating through the nanopore. Within this geometry, the shape, size, and position of the nanopore as well as the edge configuration influences the membrane conductance caused by the electrostatic interaction between the DNA nucleotides and the nanopore edge. It is shown that the graphene conductance variations resulting from DNA translocation can be enhanced by choosing a particular geometry as well as by modulating the graphene Fermi energy, which demonstrates the ability to detect conformational transformations of a double-stranded DNA, as well as the passage of individual base pairs of a single-stranded DNA molecule through the nanopore.

Original languageEnglish (US)
Article number134005
Issue number13
StatePublished - Mar 11 2015


  • DNA
  • Graphene membrane
  • Multi-scale model
  • Solid-state nanopore

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering


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