Tumor suppressor function of RUNX3 in breast cancer

Research output: Contribution to journalArticlepeer-review

Abstract

Emerging evidence indicates that RUNX3 is a tumor suppressor in breast cancer. RUNX3 is frequently inactivated in human breast cancer cell lines and cancer samples by hemizygous deletion of the Runx3 gene, hypermethylation of the Runx3 promoter, or cytoplasmic sequestration of RUNX3 protein. Inactivation of RUNX3 is associated with the initiation and progression of breast cancer. Female Runx3 +/- mice spontaneously develop ductal carcinoma, and overexpression of RUNX3 inhibits the proliferation, tumorigenic potential, and invasiveness of breast cancer cells. This review is intended to summarize these findings and discuss the tumor suppressor function of RUNX3 in breast cancer.

Original languageEnglish (US)
Pages (from-to)1470-1477
Number of pages8
JournalJournal of Cellular Biochemistry
Volume113
Issue number5
DOIs
StatePublished - May 2012

Keywords

  • BREAST CANCER
  • ESTROGEN RECEPTOR
  • INACTIVATION
  • RUNX3
  • TUMOR SUPPRESSOR

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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