Tumor necrosis factorα and insulin-like growth factor-I in the brain: Is the whole greater than the sum of its parts?

Homer D. Venters, Suzanne R. Broussard, Jian Hua Zhou, Rose Marie Bluthé, Gregory G. Freund, Rodney W. Johnson, Robert Dantzer, Keith W. Kelley

Research output: Contribution to journalReview articlepeer-review

Abstract

The cytokine tumor necrosis factorα (TNFα) and the hormone insulin-like growth factor-I (IGF-I) have both been shown to regulate inflammatory events in the central nervous system (CNS). This review summarizes the seemingly independent roles of TNFα and IGF-I in promoting and inhibiting neurodegenerative diseases. We then offer evidence that the combined effects of IGF-I and TNFα on neuronal survival can be vastly different when both receptors are stimulated simultaneously, as is likely to occur in vivo. We propose the framework of a molecular model of hormone-cytokine receptor cross talk in which disparate cell surface receptors share intracellular substrates that regulate neuronal survival.

Original languageEnglish (US)
Pages (from-to)151-165
Number of pages15
JournalJournal of Neuroimmunology
Volume119
Issue number2
DOIs
StatePublished - Oct 1 2001

Keywords

  • AIDS dementia
  • Alzheimer's disease
  • Cytokines
  • Hormones
  • Ischemic and traumatic injury
  • Multiple sclerosis
  • Receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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