Tumefaction of the dural sinuses associated with a coagulopathy following treatment of hydrocephalus in a perinate: Case report

William C. Hanigan, Ken Fraser, Michael Tarantino, Huan Wang

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The authors describe an infant with abnormal development of the cerebral venous system associated with in utero ventriculomegaly and perinatal hemorrhage. When the patient was 6 weeks of age progressive ventriculomegaly followed by cerebrospinal fluid diversion resulted in tumefaction of the dural sinuses, intravascular thrombosis, and a coagulopathy. Oral anticoagulation therapy safely reversed the coagulopathy. Serial neuroimaging findings in this unique cascade of pathophysiological events indicated that, despite decreased intracranial pressure after shunt placement, local hemodynamic factors increased the venous resistance to flow and prolonged the transit time. Long-term anticoagulation therapy was associated with improvements in flow, transit time, and tumefaction.

    Original languageEnglish (US)
    Pages (from-to)426-430
    Number of pages5
    JournalJournal of Neurosurgery
    Volume102 PEDIATRICS
    Issue numberSUPPL. 4
    StatePublished - May 1 2005

    Keywords

    • Dural sinus
    • Hydrocephalus
    • Pediatric neurosurgery
    • Shunt

    ASJC Scopus subject areas

    • Surgery
    • Clinical Neurology

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