Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells

Rahul Palchaudhuri; Paul J. Hergenrother

doi:10.1016/j.bmcl.2008.07.128

Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells

Rahul Palchaudhuri, Paul J. Hergenrother

Research output: Contribution to journal › Article › peer-review

Abstract

Triphenylmethylamides (TPMAs) have been previously identified as compounds that arrest cells in the G1-phase of the cell cycle and induce apoptotic death in melanoma cell lines in culture. Here we report the synthesis of a series of TPMA derivatives, allowing the structure-activity relationship of this class of molecules to be established. Several new compounds have been identified that induce death in UACC-62 and SK-MEL-5 human melanoma cell lines, including a compound with enhanced aqueous solubility.

Original language	English (US)
Pages (from-to)	5888-5891
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2008.07.128
State	Published - Nov 15 2008

Keywords

Anticancer compound
Anticancer drug
Apoptosis
Cancer
Melanoma
Pro-apoptotic

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2008.07.128

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title = "Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells",

abstract = "Triphenylmethylamides (TPMAs) have been previously identified as compounds that arrest cells in the G1-phase of the cell cycle and induce apoptotic death in melanoma cell lines in culture. Here we report the synthesis of a series of TPMA derivatives, allowing the structure-activity relationship of this class of molecules to be established. Several new compounds have been identified that induce death in UACC-62 and SK-MEL-5 human melanoma cell lines, including a compound with enhanced aqueous solubility.",

keywords = "Anticancer compound, Anticancer drug, Apoptosis, Cancer, Melanoma, Pro-apoptotic",

author = "Rahul Palchaudhuri and Hergenrother, {Paul J.}",

note = "Funding Information: We acknowledge the assistance of the cell flow cytometry and mass spectrometry facilities at the University of Illinois, Urbana–Champaign. We are grateful to the American Cancer Society (RSG-07-026-01) for funding this work. ",

year = "2008",

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doi = "10.1016/j.bmcl.2008.07.128",

language = "English (US)",

volume = "18",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Triphenylmethylamides (TPMAs)

T2 - Structure-activity relationship of compounds that induce apoptosis in melanoma cells

AU - Palchaudhuri, Rahul

AU - Hergenrother, Paul J.

N1 - Funding Information: We acknowledge the assistance of the cell flow cytometry and mass spectrometry facilities at the University of Illinois, Urbana–Champaign. We are grateful to the American Cancer Society (RSG-07-026-01) for funding this work.

PY - 2008/11/15

Y1 - 2008/11/15

N2 - Triphenylmethylamides (TPMAs) have been previously identified as compounds that arrest cells in the G1-phase of the cell cycle and induce apoptotic death in melanoma cell lines in culture. Here we report the synthesis of a series of TPMA derivatives, allowing the structure-activity relationship of this class of molecules to be established. Several new compounds have been identified that induce death in UACC-62 and SK-MEL-5 human melanoma cell lines, including a compound with enhanced aqueous solubility.

AB - Triphenylmethylamides (TPMAs) have been previously identified as compounds that arrest cells in the G1-phase of the cell cycle and induce apoptotic death in melanoma cell lines in culture. Here we report the synthesis of a series of TPMA derivatives, allowing the structure-activity relationship of this class of molecules to be established. Several new compounds have been identified that induce death in UACC-62 and SK-MEL-5 human melanoma cell lines, including a compound with enhanced aqueous solubility.

KW - Anticancer compound

KW - Anticancer drug

KW - Apoptosis

KW - Cancer

KW - Melanoma

KW - Pro-apoptotic

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Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells

Abstract

Keywords

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