Treatment of respiratory infections in horses with ceftiofur sodium

S. D. FOLZ, B. J. HANSON, A. K. GRIFFIN, L. L. DINVALD, T. W. SWERCZEK, R. D. WALKER, J. H. FOREMAN

Research output: Contribution to journalArticle

Abstract

Ceftiofur sodium was evaluated as a therapy for respiratory infections in horses. This cephalosporin antimicrobial was administered intramuscularly every 24 h and at a dose of 2.2 mg/kg (1.0 mg/lb) of body weight. The efficacy of ceftiofur sodium was compared with that of a positive control drug, ampicillin sodium (recommended dose of 6.6 mg/kg [3 mg/lb], given every 12 h). Both treatments were continued for 48 h after clinical symptoms were no longer evident (maximum of 10 days). Fifty‐five (55) horses with naturally acquired respiratory infections were included in the study; 28 were treated with ceftiofur and 27 with ampicillin. Clinical improvement was recorded for 92.9% of the patients treated with ceftiofur and 92.6% of the animals receiving ampicillin. Both therapies reduced body temperatures to an afebrile level after 2 days of treatment. Complete recovery/cure was noted for 78.6% of the ceftiofur patients and 59.3% of the horses treated with ampicillin. Supporting variables (depression/malaise, respiration/dyspnoea, nasal discharge) were assessed and these also substantiated the effectiveness of the treatments. Both antibiotics were well tolerated. Neither pain nor swelling were noted at the ceftiofur injection site(s). None of the animals developed diarrhoea. Data from this study indicated that ceftiofur sodium is an effective and safe treatment for respiratory infections in horses.

Original languageEnglish (US)
Pages (from-to)300-304
Number of pages5
JournalEquine veterinary journal
Volume24
Issue number4
DOIs
StatePublished - Jul 1992

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ceftiofur
Respiratory Tract Infections
Horses
horses
Ampicillin
ampicillin
infection
Therapeutics
cephalosporins
therapeutics
injection site
Drug and Narcotic Control
dyspnea
Cephalosporins
dosage
Body Temperature
Nose
Dyspnea
body temperature
signs and symptoms (animals and humans)

ASJC Scopus subject areas

  • Equine

Cite this

FOLZ, S. D., HANSON, B. J., GRIFFIN, A. K., DINVALD, L. L., SWERCZEK, T. W., WALKER, R. D., & FOREMAN, J. H. (1992). Treatment of respiratory infections in horses with ceftiofur sodium. Equine veterinary journal, 24(4), 300-304. https://doi.org/10.1111/j.2042-3306.1992.tb02840.x

Treatment of respiratory infections in horses with ceftiofur sodium. / FOLZ, S. D.; HANSON, B. J.; GRIFFIN, A. K.; DINVALD, L. L.; SWERCZEK, T. W.; WALKER, R. D.; FOREMAN, J. H.

In: Equine veterinary journal, Vol. 24, No. 4, 07.1992, p. 300-304.

Research output: Contribution to journalArticle

FOLZ, SD, HANSON, BJ, GRIFFIN, AK, DINVALD, LL, SWERCZEK, TW, WALKER, RD & FOREMAN, JH 1992, 'Treatment of respiratory infections in horses with ceftiofur sodium', Equine veterinary journal, vol. 24, no. 4, pp. 300-304. https://doi.org/10.1111/j.2042-3306.1992.tb02840.x
FOLZ SD, HANSON BJ, GRIFFIN AK, DINVALD LL, SWERCZEK TW, WALKER RD et al. Treatment of respiratory infections in horses with ceftiofur sodium. Equine veterinary journal. 1992 Jul;24(4):300-304. https://doi.org/10.1111/j.2042-3306.1992.tb02840.x
FOLZ, S. D. ; HANSON, B. J. ; GRIFFIN, A. K. ; DINVALD, L. L. ; SWERCZEK, T. W. ; WALKER, R. D. ; FOREMAN, J. H. / Treatment of respiratory infections in horses with ceftiofur sodium. In: Equine veterinary journal. 1992 ; Vol. 24, No. 4. pp. 300-304.
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