Treatment of fungal-infected diabetic wounds with low temperature plasma

Kyu Young Choi, Md Tipu Sultan, Olatunji Ajiteru, Heesun Hong, Young Jin Lee, Ji Seung Lee, Hanna Lee, Ok Joo Lee, Soon Hee Kim, Joong Seob Lee, Sung Jin Park, James Gary Eden, Chan Hum Park

Research output: Contribution to journalArticlepeer-review


Diabetes mellitus renders patients susceptible to chronic wounds and various infections. Regarding the latter, fungal infections are of particular concern since, although they are the source of significant morbidity and mortality in immunocompromised patients, they are generally resistant to conventional treatment and a definite treatment strategy has not yet been established. Herein, we report the treatment of skin wounds in a diabetic rat model, infected by Candida albicans, with low temperature helium plasma generated in a hand-held atmospheric jet device. A fungal infection was induced on two dorsal skin wounds of the diabetic rats, and one wound was treated with the plasma jet whereas the other served as a control. Histological analysis revealed accelerated skin wound healing and decreased evidence of fungal infection in the plasma-treated group, as compared to the control group. Regeneration of the epidermis and dermis, collagen deposition, and neovascularization were all observed as a result of plasma treatment, but without wound contraction, scar formation or any evidence of thermal damage to the tissue. These findings demonstrate that the He plasma jet is remarkably effective in diabetic skin wounds infected by Candida albicans, thereby providing a promising medical treatment option for diabetes mellitus patients with skin wound and fungal infections.

Original languageEnglish (US)
Article number27
Issue number1
StatePublished - Jan 2022


  • Candida albicans
  • Diabetes mellitus
  • Low temperature plasma
  • Skin
  • Wound healing

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Biochemistry, Genetics and Molecular Biology


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