Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012)

S. A. Collette; S. D. Allstadt; E. M. Chon; W. Vernau; A. N. Smith; L. D. Garrett; K. Choy; R. B. Rebhun; C. O. Rodriguez; K. A. Skorupski

doi:10.1111/vco.12158

Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012)

S. A. Collette, S. D. Allstadt, E. M. Chon, W. Vernau, A. N. Smith, L. D. Garrett, K. Choy, R. B. Rebhun, C. O. Rodriguez, K. A. Skorupski

Research output: Contribution to journal › Article › peer-review

Abstract

CHOP-based (cyclophosphamide, doxorubicin, vinca alkaloid, prednisolone) chemotherapy protocols are often recommended for treatment of feline lymphoma. While maintenance-free CHOP-based protocols have been published and readily used in dogs, there is limited literature regarding similar maintenance-free protocols in cats. The purpose of this study was to describe the outcome of cats with intermediate- to high-grade lymphoma that were prescribed a modified 25-week University of Wisconsin-Madison (UW-25) chemotherapy protocol. A secondary objective was examination of potential prognostic factors. One hundred and nineteen cats from five institutions treated with a UW-25-based protocol were included. The Kaplan-Meier median progression-free interval (PFI) and survival time (MST) were 56 and 97 (range 2-2019) days, respectively. Cats assessed as having a complete response (CR) to therapy had significantly longer PFI and MST than those with partial or no response (PFI 205 versus 54 versus 21 days, respectively, P < 0.0001 and MST 318 versus 85 versus 27 days, respectively, P < 0.0001).

Original language	English (US)
Pages (from-to)	136-146
Number of pages	11
Journal	Veterinary and comparative oncology
Volume	14
DOIs	https://doi.org/10.1111/vco.12158
State	Published - Aug 1 2016

Keywords

CHOP
cat
feline
lymphoma
maintenance-free chemotherapy
survival

ASJC Scopus subject areas

General Veterinary

Online availability

10.1111/vco.12158

Library availability

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Cite this

Collette, S. A., Allstadt, S. D., Chon, E. M., Vernau, W., Smith, A. N., Garrett, L. D., Choy, K., Rebhun, R. B., Rodriguez, C. O., & Skorupski, K. A. (2016). Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012). Veterinary and comparative oncology, 14, 136-146. https://doi.org/10.1111/vco.12158

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abstract = "CHOP-based (cyclophosphamide, doxorubicin, vinca alkaloid, prednisolone) chemotherapy protocols are often recommended for treatment of feline lymphoma. While maintenance-free CHOP-based protocols have been published and readily used in dogs, there is limited literature regarding similar maintenance-free protocols in cats. The purpose of this study was to describe the outcome of cats with intermediate- to high-grade lymphoma that were prescribed a modified 25-week University of Wisconsin-Madison (UW-25) chemotherapy protocol. A secondary objective was examination of potential prognostic factors. One hundred and nineteen cats from five institutions treated with a UW-25-based protocol were included. The Kaplan-Meier median progression-free interval (PFI) and survival time (MST) were 56 and 97 (range 2-2019) days, respectively. Cats assessed as having a complete response (CR) to therapy had significantly longer PFI and MST than those with partial or no response (PFI 205 versus 54 versus 21 days, respectively, P < 0.0001 and MST 318 versus 85 versus 27 days, respectively, P < 0.0001).",

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