Transthoracic cardiac ultrasonic stimulation induces a negative chronotropic effect

Elaine Belassiano Buiochi; Rita J. Miller; Emily Hartman; Flavio Buiochi; Rosana Bassani; Eduardo T. Costa; William D. O'Brien

doi:10.1109/TUFFC.2012.2506

Transthoracic cardiac ultrasonic stimulation induces a negative chronotropic effect

Elaine Belassiano Buiochi, Rita J. Miller, Emily Hartman, Flavio Buiochi, Rosana Bassani, Eduardo T. Costa, William D. O'Brien

Research output: Contribution to journal › Article › peer-review

Abstract

The objective of this study is to investigate cardiac bioeffects resulting from ultrasonic stimulation using a specific set of acoustical parameters. Ten Sprague-Dawley rats were anesthetized and exposed to 1-MHz ultrasound pulses of 3-MPa peak rarefactional pressure and approximately 1% duty factor. The pulse repetition frequency started slightly above the heart rate and was decreased by 1 Hz every 10 s, for a total exposure duration of 30 s. The control group was composed of five rats. Two-way analysis of variance for repeated measures and Bonferroni post hoc tests were used to compare heart rate and ejection fraction, which was used as an index of myocardial contractility. It was demonstrated for the first time that transthoracic ultrasound has the potential to decrease the heart rate by 20%. The negative chronotropic effect lasted for at least 15 min after ultrasound exposure and there was no apparent gross damage to the cardiac tissue.

Original language	English (US)
Article number	6373788
Pages (from-to)	2655-2661
Number of pages	7
Journal	IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume	59
Issue number	12
DOIs	https://doi.org/10.1109/TUFFC.2012.2506
State	Published - 2012

ASJC Scopus subject areas

Instrumentation
Acoustics and Ultrasonics
Electrical and Electronic Engineering

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10.1109/TUFFC.2012.2506

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title = "Transthoracic cardiac ultrasonic stimulation induces a negative chronotropic effect",

abstract = "The objective of this study is to investigate cardiac bioeffects resulting from ultrasonic stimulation using a specific set of acoustical parameters. Ten Sprague-Dawley rats were anesthetized and exposed to 1-MHz ultrasound pulses of 3-MPa peak rarefactional pressure and approximately 1% duty factor. The pulse repetition frequency started slightly above the heart rate and was decreased by 1 Hz every 10 s, for a total exposure duration of 30 s. The control group was composed of five rats. Two-way analysis of variance for repeated measures and Bonferroni post hoc tests were used to compare heart rate and ejection fraction, which was used as an index of myocardial contractility. It was demonstrated for the first time that transthoracic ultrasound has the potential to decrease the heart rate by 20%. The negative chronotropic effect lasted for at least 15 min after ultrasound exposure and there was no apparent gross damage to the cardiac tissue.",

author = "Buiochi, {Elaine Belassiano} and Miller, {Rita J.} and Emily Hartman and Flavio Buiochi and Rosana Bassani and Costa, {Eduardo T.} and O'Brien, {William D.}",

note = "Funding Information: manuscript received January 19, 2012; accepted august 10, 2012. This work was supported by the national Institutes of Health (nIH grants r37 Eb002641 and s10 rr027884) and by the sao Paulo research Foundation (FaPEsP grant 06/60032-0). E. b. buiochi and E. T. costa are with the department of biomedical Engineering, University of campinas, campinas, brazil (e-mail: elaine@ ceb.unicamp.br). r. J. miller and W. d. o{\textquoteright}brien, Jr. are with the department of Electrical and computer Engineering, University of Illinois at Urbana– champaign, Urbana, Il. E. Hartman is with the biomedical Imaging center, beckman Institute, University of Illinois at Urbana–champaign, Urbana, Il. F. buiochi is with the department of mechatronics Engineering, University of sao Paulo, sao Paulo, brazil. r. a. bassani, E. T. costa are with the center for biomedical Engineering, University of campinas, brazil. doI http://dx.doi.org/10.1109/TUFFc.2012.2506",

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AU - Bassani, Rosana

AU - Costa, Eduardo T.

AU - O'Brien, William D.

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Transthoracic cardiac ultrasonic stimulation induces a negative chronotropic effect

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