Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway

Anne Cheever, Stephanie Ceman

Research output: Contribution to journalReview articlepeer-review


Small, genomically-encoded microRNAs are important factors in the regulation of mRNA translation. Although their biogenesis is relatively well-defined, it is still unclear how they are recruited to their mRNA targets. The fragile X mental retardation protein family members, FMRP, FXR1P and FXR2P are RNA binding proteins that regulate translation of their cargo mRNAs. All three proteins, in addition to the single Drosophila ortholog, dFmrp, associate physically and functionally with the microRNA pathway. In this review, we summarize what is known about the role of the fragile X family members in translation regulation, highlighting evidence for their association with the microRNA pathway. In addition, we present a new model for the effect of phosphorylation on FMRP function, where phosphorylation of FMRP inhibits Dicer binding, leading to the accumulation of precursor microRNAs and possibly a paucity of activating microRNAs.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalRNA Biology
Issue number2
StatePublished - 2009


  • FMRP
  • FXR1P
  • Microrna
  • Mrna
  • Phosphorylation
  • Translation regulation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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