Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway

Anne Cheever, Stephanie Ceman

Research output: Contribution to journalReview article

Abstract

Small, genomically-encoded microRNAs are important factors in the regulation of mRNA translation. Although their biogenesis is relatively well-defined, it is still unclear how they are recruited to their mRNA targets. The fragile X mental retardation protein family members, FMRP, FXR1P and FXR2P are RNA binding proteins that regulate translation of their cargo mRNAs. All three proteins, in addition to the single Drosophila ortholog, dFmrp, associate physically and functionally with the microRNA pathway. In this review, we summarize what is known about the role of the fragile X family members in translation regulation, highlighting evidence for their association with the microRNA pathway. In addition, we present a new model for the effect of phosphorylation on FMRP function, where phosphorylation of FMRP inhibits Dicer binding, leading to the accumulation of precursor microRNAs and possibly a paucity of activating microRNAs.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalRNA Biology
Volume6
Issue number2
DOIs
StatePublished - Jan 1 2009

Fingerprint

Protein Biosynthesis
MicroRNAs
Proteins
Fragile X Mental Retardation Protein
Phosphorylation
Messenger RNA
RNA-Binding Proteins
Drosophila

Keywords

  • FMRP
  • FXR1P
  • Microrna
  • Mrna
  • Phosphorylation
  • Translation regulation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway. / Cheever, Anne; Ceman, Stephanie.

In: RNA Biology, Vol. 6, No. 2, 01.01.2009, p. 175-178.

Research output: Contribution to journalReview article

@article{b444f521881147debe4b80b56767e92a,
title = "Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway",
abstract = "Small, genomically-encoded microRNAs are important factors in the regulation of mRNA translation. Although their biogenesis is relatively well-defined, it is still unclear how they are recruited to their mRNA targets. The fragile X mental retardation protein family members, FMRP, FXR1P and FXR2P are RNA binding proteins that regulate translation of their cargo mRNAs. All three proteins, in addition to the single Drosophila ortholog, dFmrp, associate physically and functionally with the microRNA pathway. In this review, we summarize what is known about the role of the fragile X family members in translation regulation, highlighting evidence for their association with the microRNA pathway. In addition, we present a new model for the effect of phosphorylation on FMRP function, where phosphorylation of FMRP inhibits Dicer binding, leading to the accumulation of precursor microRNAs and possibly a paucity of activating microRNAs.",
keywords = "FMRP, FXR1P, Microrna, Mrna, Phosphorylation, Translation regulation",
author = "Anne Cheever and Stephanie Ceman",
year = "2009",
month = "1",
day = "1",
doi = "10.4161/rna.6.2.8196",
language = "English (US)",
volume = "6",
pages = "175--178",
journal = "RNA Biology",
issn = "1547-6286",
publisher = "Landes Bioscience",
number = "2",

}

TY - JOUR

T1 - Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway

AU - Cheever, Anne

AU - Ceman, Stephanie

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Small, genomically-encoded microRNAs are important factors in the regulation of mRNA translation. Although their biogenesis is relatively well-defined, it is still unclear how they are recruited to their mRNA targets. The fragile X mental retardation protein family members, FMRP, FXR1P and FXR2P are RNA binding proteins that regulate translation of their cargo mRNAs. All three proteins, in addition to the single Drosophila ortholog, dFmrp, associate physically and functionally with the microRNA pathway. In this review, we summarize what is known about the role of the fragile X family members in translation regulation, highlighting evidence for their association with the microRNA pathway. In addition, we present a new model for the effect of phosphorylation on FMRP function, where phosphorylation of FMRP inhibits Dicer binding, leading to the accumulation of precursor microRNAs and possibly a paucity of activating microRNAs.

AB - Small, genomically-encoded microRNAs are important factors in the regulation of mRNA translation. Although their biogenesis is relatively well-defined, it is still unclear how they are recruited to their mRNA targets. The fragile X mental retardation protein family members, FMRP, FXR1P and FXR2P are RNA binding proteins that regulate translation of their cargo mRNAs. All three proteins, in addition to the single Drosophila ortholog, dFmrp, associate physically and functionally with the microRNA pathway. In this review, we summarize what is known about the role of the fragile X family members in translation regulation, highlighting evidence for their association with the microRNA pathway. In addition, we present a new model for the effect of phosphorylation on FMRP function, where phosphorylation of FMRP inhibits Dicer binding, leading to the accumulation of precursor microRNAs and possibly a paucity of activating microRNAs.

KW - FMRP

KW - FXR1P

KW - Microrna

KW - Mrna

KW - Phosphorylation

KW - Translation regulation

UR - http://www.scopus.com/inward/record.url?scp=66349104309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66349104309&partnerID=8YFLogxK

U2 - 10.4161/rna.6.2.8196

DO - 10.4161/rna.6.2.8196

M3 - Review article

C2 - 19276651

AN - SCOPUS:66349104309

VL - 6

SP - 175

EP - 178

JO - RNA Biology

JF - RNA Biology

SN - 1547-6286

IS - 2

ER -