Transgenic and targeted mutant mice in drug discovery

Uwe Rudolph, Hanns Mohler

Research output: Contribution to journalArticlepeer-review


In the process of drug discovery, different classes of genetically- modified animals are valuable tools for the identification of drug targets, distinction of target isoforms, differentiation of signaling pathways, generation of disease models and toxicological testing. The analysis is refined by methodologies which permit the inducible regulation of gene expression in a time- and tissue-specific manner. Finally, multiflexing techniques and knockout embryonic stem (ES) cell libraries will help to link DNA sequence information to biological function.

Original languageEnglish (US)
Pages (from-to)134-141
Number of pages8
JournalCurrent Opinion in Drug Discovery and Development
Issue number2
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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