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Transformation-Guided Genome Mining Provides Access to Brominated Lanthipeptides
Nirmal Saha
, F. N.U. Vidya
, Youran Luo
,
Wilfred A. van der Donk
, Vinayak Agarwal
Chemistry
Biomedical and Translational Sciences
Carl R. Woese Institute for Genomic Biology
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Keyphrases
Genome Mining
100%
Lanthipeptide
100%
Brominated
100%
Macrocyclic Peptides
100%
Peptide Substrate
66%
Halogenase
66%
Side Chain
33%
Indole
33%
Tryptophan
33%
Chemical Catalysis
33%
Suzuki-Miyaura Coupling
33%
Chemical Transformation
33%
Biocatalytic
33%
Aryl Bromides
33%
Arylation
33%
Natural Product Biosynthesis
33%
Linear Peptide
33%
Tinkering
33%
Chemistry
Chemical Transformation
100%
Indole
100%
Arylation
100%
Natural Product
100%
Tryptophan
100%
Suzuki Reaction
100%
Biochemistry, Genetics and Molecular Biology
Anabolism
100%
Enzyme
100%
Suzuki Reaction
100%
Arylation
100%
Tryptophan
100%