Transdiagnostic dimensions of anxiety: Neural mechanisms, executive functions, and new directions

Paul B. Sharp, Gregory A. Miller, Wendy Heller

Research output: Contribution to journalArticle

Abstract

Converging neuroscientific and psychological evidence points to several transdiagnostic factors that cut across DSM-defined disorders, which both affect and are affected by executive dysfunction. Two of these factors, anxious apprehension and anxious arousal, have helped bridge the gap between psychological and neurobiological models of anxiety. The present integration of diverse findings advances an understanding of the relationships between these transdiagnostic anxiety dimensions, their interactions with each other and executive function, and their neural mechanisms. Additionally, a discussion is provided concerning how these constructs fit within the Research Domain Criteria (RDoC) matrix developed by the National Institutes of Mental Health and how they relate to other anxiety constructs studied with different methods and at other units of analysis. Suggestions for future research are offered, including how to (1) improve measurement and delineation of these constructs, (2) use new neuroimaging methods and theoretical approaches of how the brain functions to build neural mechanistic models of these constructs, and (3) advance understanding of the relationships of these constructs to diverse emotional phenomena and executive functions.

Original languageEnglish (US)
Pages (from-to)365-377
Number of pages13
JournalInternational Journal of Psychophysiology
Volume98
Issue number2
DOIs
StatePublished - Nov 2015

Fingerprint

Executive Function
Anxiety
Psychological Models
National Institute of Mental Health (U.S.)
Arousal
Neuroimaging
Psychology
Brain
Research
Direction compound

Keywords

  • Anxious apprehension
  • Anxious arousal
  • Executive function
  • Neural mechanisms
  • RDoC
  • Transdiagnostic

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Physiology (medical)

Cite this

Transdiagnostic dimensions of anxiety : Neural mechanisms, executive functions, and new directions. / Sharp, Paul B.; Miller, Gregory A.; Heller, Wendy.

In: International Journal of Psychophysiology, Vol. 98, No. 2, 11.2015, p. 365-377.

Research output: Contribution to journalArticle

@article{7bac444f60fb4c07abdf07a887d65b30,
title = "Transdiagnostic dimensions of anxiety: Neural mechanisms, executive functions, and new directions",
abstract = "Converging neuroscientific and psychological evidence points to several transdiagnostic factors that cut across DSM-defined disorders, which both affect and are affected by executive dysfunction. Two of these factors, anxious apprehension and anxious arousal, have helped bridge the gap between psychological and neurobiological models of anxiety. The present integration of diverse findings advances an understanding of the relationships between these transdiagnostic anxiety dimensions, their interactions with each other and executive function, and their neural mechanisms. Additionally, a discussion is provided concerning how these constructs fit within the Research Domain Criteria (RDoC) matrix developed by the National Institutes of Mental Health and how they relate to other anxiety constructs studied with different methods and at other units of analysis. Suggestions for future research are offered, including how to (1) improve measurement and delineation of these constructs, (2) use new neuroimaging methods and theoretical approaches of how the brain functions to build neural mechanistic models of these constructs, and (3) advance understanding of the relationships of these constructs to diverse emotional phenomena and executive functions.",
keywords = "Anxious apprehension, Anxious arousal, Executive function, Neural mechanisms, RDoC, Transdiagnostic",
author = "Sharp, {Paul B.} and Miller, {Gregory A.} and Wendy Heller",
year = "2015",
month = "11",
doi = "10.1016/j.ijpsycho.2015.07.001",
language = "English (US)",
volume = "98",
pages = "365--377",
journal = "International Journal of Psychophysiology",
issn = "0167-8760",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Transdiagnostic dimensions of anxiety

T2 - Neural mechanisms, executive functions, and new directions

AU - Sharp, Paul B.

AU - Miller, Gregory A.

AU - Heller, Wendy

PY - 2015/11

Y1 - 2015/11

N2 - Converging neuroscientific and psychological evidence points to several transdiagnostic factors that cut across DSM-defined disorders, which both affect and are affected by executive dysfunction. Two of these factors, anxious apprehension and anxious arousal, have helped bridge the gap between psychological and neurobiological models of anxiety. The present integration of diverse findings advances an understanding of the relationships between these transdiagnostic anxiety dimensions, their interactions with each other and executive function, and their neural mechanisms. Additionally, a discussion is provided concerning how these constructs fit within the Research Domain Criteria (RDoC) matrix developed by the National Institutes of Mental Health and how they relate to other anxiety constructs studied with different methods and at other units of analysis. Suggestions for future research are offered, including how to (1) improve measurement and delineation of these constructs, (2) use new neuroimaging methods and theoretical approaches of how the brain functions to build neural mechanistic models of these constructs, and (3) advance understanding of the relationships of these constructs to diverse emotional phenomena and executive functions.

AB - Converging neuroscientific and psychological evidence points to several transdiagnostic factors that cut across DSM-defined disorders, which both affect and are affected by executive dysfunction. Two of these factors, anxious apprehension and anxious arousal, have helped bridge the gap between psychological and neurobiological models of anxiety. The present integration of diverse findings advances an understanding of the relationships between these transdiagnostic anxiety dimensions, their interactions with each other and executive function, and their neural mechanisms. Additionally, a discussion is provided concerning how these constructs fit within the Research Domain Criteria (RDoC) matrix developed by the National Institutes of Mental Health and how they relate to other anxiety constructs studied with different methods and at other units of analysis. Suggestions for future research are offered, including how to (1) improve measurement and delineation of these constructs, (2) use new neuroimaging methods and theoretical approaches of how the brain functions to build neural mechanistic models of these constructs, and (3) advance understanding of the relationships of these constructs to diverse emotional phenomena and executive functions.

KW - Anxious apprehension

KW - Anxious arousal

KW - Executive function

KW - Neural mechanisms

KW - RDoC

KW - Transdiagnostic

UR - http://www.scopus.com/inward/record.url?scp=84937622231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937622231&partnerID=8YFLogxK

U2 - 10.1016/j.ijpsycho.2015.07.001

DO - 10.1016/j.ijpsycho.2015.07.001

M3 - Article

C2 - 26156938

AN - SCOPUS:84937622231

VL - 98

SP - 365

EP - 377

JO - International Journal of Psychophysiology

JF - International Journal of Psychophysiology

SN - 0167-8760

IS - 2

ER -