Transdermal clonidine for ameliorating tamoxifen-induced hot flashes

Richard M. Goldberg; Charles L. Loprinzi; Judith R. O'Fallon; Michael H. Veeder; Angela W. Miser; James A. Mailliard; John C. Michalak; Ann Marie Dose; Ken M. Rowland; Nora L. Burnham

doi:10.1200/JCO.1994.12.1.155

Transdermal clonidine for ameliorating tamoxifen-induced hot flashes

Richard M. Goldberg, Charles L. Loprinzi, Judith R. O'Fallon, Michael H. Veeder, Angela W. Miser, James A. Mailliard, John C. Michalak, Ann Marie Dose, Ken M. Rowland, Nora L. Burnham

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To determine the efficacy of transdermal clonidine for alleviating tamoxifen-induced hot flashes in women with a history of breast cancer. Patients and Methods: A randomized, double-blind, crossover design was used in this prospective study. Women with a history of breast cancer who were receiving tamoxifen and suffering from hot flashes were potentially eligible for this protocol study. Results: Clonidine did reduce hot-flash frequency to a degree that was statistically impressive (P < .0001), but clinically moderate (20% reduction from baseline). It also decreased hot- flash severity (P = .02, 10% reduction from baseline). Clonidine was related to increased mouth dryness (P < .001), constipation (P < .02), itchiness under the patch (P < .01), and drowsiness (P < .05). Conclusion: Better means are needed to alleviate hot flashes among patients in whom estrogen therapy is contraindicated.

Original language	English (US)
Pages (from-to)	155-158
Number of pages	4
Journal	Journal of Clinical Oncology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1200/JCO.1994.12.1.155
State	Published - Jan 1994
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1200/JCO.1994.12.1.155

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title = "Transdermal clonidine for ameliorating tamoxifen-induced hot flashes",

abstract = "Purpose: To determine the efficacy of transdermal clonidine for alleviating tamoxifen-induced hot flashes in women with a history of breast cancer. Patients and Methods: A randomized, double-blind, crossover design was used in this prospective study. Women with a history of breast cancer who were receiving tamoxifen and suffering from hot flashes were potentially eligible for this protocol study. Results: Clonidine did reduce hot-flash frequency to a degree that was statistically impressive (P < .0001), but clinically moderate (20% reduction from baseline). It also decreased hot- flash severity (P = .02, 10% reduction from baseline). Clonidine was related to increased mouth dryness (P < .001), constipation (P < .02), itchiness under the patch (P < .01), and drowsiness (P < .05). Conclusion: Better means are needed to alleviate hot flashes among patients in whom estrogen therapy is contraindicated.",

author = "Goldberg, {Richard M.} and Loprinzi, {Charles L.} and O'Fallon, {Judith R.} and Veeder, {Michael H.} and Miser, {Angela W.} and Mailliard, {James A.} and Michalak, {John C.} and Dose, {Ann Marie} and Rowland, {Ken M.} and Burnham, {Nora L.}",

year = "1994",

month = jan,

doi = "10.1200/JCO.1994.12.1.155",

language = "English (US)",

volume = "12",

pages = "155--158",

journal = "Journal of Clinical Oncology",

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publisher = "Lippincott Williams and Wilkins",

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T1 - Transdermal clonidine for ameliorating tamoxifen-induced hot flashes

AU - Goldberg, Richard M.

AU - Loprinzi, Charles L.

AU - O'Fallon, Judith R.

AU - Veeder, Michael H.

AU - Miser, Angela W.

AU - Mailliard, James A.

AU - Michalak, John C.

AU - Dose, Ann Marie

AU - Rowland, Ken M.

AU - Burnham, Nora L.

PY - 1994/1

Y1 - 1994/1

N2 - Purpose: To determine the efficacy of transdermal clonidine for alleviating tamoxifen-induced hot flashes in women with a history of breast cancer. Patients and Methods: A randomized, double-blind, crossover design was used in this prospective study. Women with a history of breast cancer who were receiving tamoxifen and suffering from hot flashes were potentially eligible for this protocol study. Results: Clonidine did reduce hot-flash frequency to a degree that was statistically impressive (P < .0001), but clinically moderate (20% reduction from baseline). It also decreased hot- flash severity (P = .02, 10% reduction from baseline). Clonidine was related to increased mouth dryness (P < .001), constipation (P < .02), itchiness under the patch (P < .01), and drowsiness (P < .05). Conclusion: Better means are needed to alleviate hot flashes among patients in whom estrogen therapy is contraindicated.

AB - Purpose: To determine the efficacy of transdermal clonidine for alleviating tamoxifen-induced hot flashes in women with a history of breast cancer. Patients and Methods: A randomized, double-blind, crossover design was used in this prospective study. Women with a history of breast cancer who were receiving tamoxifen and suffering from hot flashes were potentially eligible for this protocol study. Results: Clonidine did reduce hot-flash frequency to a degree that was statistically impressive (P < .0001), but clinically moderate (20% reduction from baseline). It also decreased hot- flash severity (P = .02, 10% reduction from baseline). Clonidine was related to increased mouth dryness (P < .001), constipation (P < .02), itchiness under the patch (P < .01), and drowsiness (P < .05). Conclusion: Better means are needed to alleviate hot flashes among patients in whom estrogen therapy is contraindicated.

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Transdermal clonidine for ameliorating tamoxifen-induced hot flashes

Abstract

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