Transcriptional regulation by the numbers: Applications

Lacramioara Bintu, Nicolas E. Buchler, Hernan G. Garcia, Ulrich Gerland, Terence Hwa, Jané Kondev, Thomas Kuhlman, Rob Phillips

Research output: Contribution to journalReview articlepeer-review

Abstract

With the increasing amount of experimental data on gene expression and regulation, there is a growing need for quantitative models to describe the data and relate them to their respective context. Thermodynamic models provide a useful framework for the quantitative analysis of bacterial transcription regulation. This framework can facilitate the quantification of vastly different forms of gene expression from several well-characterized bacterial promoters that are regulated by one or two species of transcription factors; it is useful because it requires only a few parameters. As such, it provides a compact description useful for higher-level studies (e.g. of genetic networks) without the need to invoke the biochemical details of every component. Moreover, it can be used to generate hypotheses on the likely mechanisms of transcriptional control.

Original languageEnglish (US)
Pages (from-to)125-135
Number of pages11
JournalCurrent Opinion in Genetics and Development
Volume15
Issue number2
DOIs
StatePublished - Apr 2005

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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