@inproceedings{b2968618226140f0ba275c3ae655d409,
title = "Transcranial photoacoustic tomography of the monkey brain",
abstract = "A photoacoustic tomography (PAT) system using a virtual point ultrasonic transducer was developed for transcranial imaging of monkey brains. The virtual point transducer provided a 10 times greater field-of-view (FOV) than finiteaperture unfocused transducers, which enables large primate imaging. The cerebral cortex of a monkey brain was accurately mapped transcranially, through up to two skulls ranging from 4 to 8 mm in thickness. The mass density and speed of sound distributions of the skull were estimated from adjunct X-ray CT image data and utilized with a timereversal algorithm to mitigate artifacts in the reconstructed image due to acoustic aberration. The oxygenation saturation (sO 2) in blood phantoms through a monkey skull was also imaged and quantified, with results consistent with measurements by a gas analyzer. The oxygenation saturation (sO 2) in blood phantoms through a monkey skull was also imaged and quantified, with results consistent with measurements by a gas analyzer. Our experimental results demonstrate that PAT can overcome the optical and ultrasound attenuation of a relatively thick skull, and the imaging aberration caused by skull can be corrected to a great extent.",
keywords = "Time-reversal image reconstruction, Transcranial photoacoustic tomography",
author = "Liming Nie and Chao Huang and Zijian Guo and Mark Anastasio and Wang, {Lihong V.}",
year = "2012",
doi = "10.1117/12.907060",
language = "English (US)",
isbn = "9780819488664",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2012 ; Conference date: 22-01-2012 Through 24-01-2012",
}