trans Activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein

H. Albrecht, A. N. Shakhov, C. V. Jongeneel

Research output: Contribution to journalComment/debate

Abstract

In a cotransfection assay, the human T-cell leukemia virus type I Tax1 gene product specifically activated transcription from the mouse tumor necrosis factor α promoter. The activation patterns of 5' deletion mutants, artificial enhancer constructs, and point mutations in the promoter indicate that the major Tax1-responsive element is a site at position -655 which binds the NF-κB/rel and NF-GMa transcription factors.

Original languageEnglish (US)
Pages (from-to)6191-6193
Number of pages3
JournalJournal of virology
Volume66
Issue number10
StatePublished - Jan 1 1992

Fingerprint

Primate T-lymphotropic virus 1
Human T-lymphotropic virus 1
transcriptional activation
Point Mutation
tumor necrosis factor-alpha
Transcription Factors
Tumor Necrosis Factor-alpha
promoter regions
tumor necrosis factors
point mutation
Genes
Proteins
transcription factors
proteins
transcription (genetics)
mutants
mice
assays
genes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

trans Activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein. / Albrecht, H.; Shakhov, A. N.; Jongeneel, C. V.

In: Journal of virology, Vol. 66, No. 10, 01.01.1992, p. 6191-6193.

Research output: Contribution to journalComment/debate

Albrecht, H. ; Shakhov, A. N. ; Jongeneel, C. V. / trans Activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein. In: Journal of virology. 1992 ; Vol. 66, No. 10. pp. 6191-6193.
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