trans Activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein

H. Albrecht, A. N. Shakhov, C. V. Jongeneel

Research output: Contribution to journalComment/debate

Abstract

In a cotransfection assay, the human T-cell leukemia virus type I Tax1 gene product specifically activated transcription from the mouse tumor necrosis factor α promoter. The activation patterns of 5' deletion mutants, artificial enhancer constructs, and point mutations in the promoter indicate that the major Tax1-responsive element is a site at position -655 which binds the NF-κB/rel and NF-GMa transcription factors.

Original languageEnglish (US)
Pages (from-to)6191-6193
Number of pages3
JournalJournal of virology
Volume66
Issue number10
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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