Overdoses of macrocyclic lactones in dogs and cats can result in such signs as tremors, ataxia, seizures, coma, and blindness. Dogs with the ABCB1-1Δ gene defect are predisposed to macrocyclic lactone toxicosis at lower dosages than dogs without the defect. Intravenous lipid emulsion therapy has been suggested for treatment of macrocyclic lactone toxicosis but evidence of efficacy is limited. Initial decontamination and supportive care remain the mainstays of therapy for macrocyclic lactone toxicosis.
|Original language||English (US)|
|Number of pages||22|
|Journal||Veterinary Clinics of North America - Small Animal Practice|
|State||Published - Nov 2018|
- Macrocyclic lactones
ASJC Scopus subject areas
- Small Animals