Toxicology of Avermectins and Milbemycins (Macrocyclic Lactones) and the Role of P-Glycoprotein in Dogs and Cats

Valentina M. Merola, Paul A. Eubig

Research output: Contribution to journalReview article

Abstract

Overdoses of macrocyclic lactones in dogs and cats can result in such signs as tremors, ataxia, seizures, coma, and blindness. Dogs with the ABCB1-1Δ gene defect are predisposed to macrocyclic lactone toxicosis at lower dosages than dogs without the defect. Intravenous lipid emulsion therapy has been suggested for treatment of macrocyclic lactone toxicosis but evidence of efficacy is limited. Initial decontamination and supportive care remain the mainstays of therapy for macrocyclic lactone toxicosis.

Original languageEnglish (US)
Pages (from-to)991-1012
Number of pages22
JournalVeterinary Clinics of North America - Small Animal Practice
Volume48
Issue number6
DOIs
StatePublished - Nov 2018

Keywords

  • Cats
  • Dogs
  • Ivermectin
  • Macrocyclic lactones
  • P-glycoprotein

ASJC Scopus subject areas

  • Small Animals

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