Towards a foundational representation of potential drug-drug interaction knowledge

Mathias Brochhausen, Jodi Schneider, Daniel Malone, Philip E. Empey, William R. Hogan, Richard D. Boyce

Research output: Contribution to journalConference articlepeer-review


Inadequate representation of evidence and knowledge about potential drug-drug interactions is a major factor underlying disagreements among sources of drug information that are used by clinicians. In this paper we describe the initial steps toward developing a foundational domain representation that allows tracing the evidence underlying potential drug-drug interaction knowledge. The new representation includes biological and biomedical entities represented in existing ontologies and terminologies to foster integration of data from relevant fields such as physiology, anatomy, and laboratory sciences.


  • Knowledge management
  • Ontologies
  • Potential drug-drug interactions

ASJC Scopus subject areas

  • General Computer Science


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