Toward an outline of the topography of a realistic protein-folding funnel

J. N. Onuchic, P. G. Wolynes, Z. Luthey-Schulten, N. D. Socci

Research output: Contribution to journalArticlepeer-review


Experimental information on the structure and dynamics of molten globules gives estimates for the energy landscapers characteristics for folding highly helical proteins, when supplemented by a theory of the helix-coil transition in collapsed heteropolymers. A law of corresponding states relating simulations on small lattice models to real proteins possessing many more degrees of freedom results. This correspondence reveals parallels between 'minimalist' lattice results and recent experimental results for the degree of native character of the folding transition state and molten globule and also pinpoints the needs of further experiments.

Original languageEnglish (US)
Pages (from-to)3626-3630
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number8
StatePublished - Apr 11 1995

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