Abstract
The choice is yours: The first total synthesis of the antioxidant carotenoid synechoxanthin was achieved through a novel iterative cross-coupling approach in which the polarity of the bifunctional building blocks is reversed to match the preferred polarity for C-C bond formation (see scheme). The convergent, stereocontrolled, and flexible nature of this synthesis enables systematic studies of the biological activities of this natural product.
Original language | English (US) |
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Pages (from-to) | 7862-7864 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 34 |
DOIs | |
State | Published - Aug 16 2011 |
Keywords
- antioxidants
- boronates
- iterative cross-coupling
- synechoxanthin
- total synthesis
ASJC Scopus subject areas
- Catalysis
- General Chemistry