Abstract
The choice is yours: The first total synthesis of the antioxidant carotenoid synechoxanthin was achieved through a novel iterative cross-coupling approach in which the polarity of the bifunctional building blocks is reversed to match the preferred polarity for C-C bond formation (see scheme). The convergent, stereocontrolled, and flexible nature of this synthesis enables systematic studies of the biological activities of this natural product.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7862-7864 |
| Number of pages | 3 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 50 |
| Issue number | 34 |
| DOIs | |
| State | Published - Aug 16 2011 |
Keywords
- antioxidants
- boronates
- iterative cross-coupling
- synechoxanthin
- total synthesis
ASJC Scopus subject areas
- Catalysis
- General Chemistry