The choice is yours: The first total synthesis of the antioxidant carotenoid synechoxanthin was achieved through a novel iterative cross-coupling approach in which the polarity of the bifunctional building blocks is reversed to match the preferred polarity for C-C bond formation (see scheme). The convergent, stereocontrolled, and flexible nature of this synthesis enables systematic studies of the biological activities of this natural product.
|Original language||English (US)|
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Aug 16 2011|
- iterative cross-coupling
- total synthesis
ASJC Scopus subject areas