Total synthesis of (S)-equol

Jennifer M. Heemstra, Sean A. Kerrigan, Daniel R. Doerge, William G. Helferich, William A. Boulanger

Research output: Contribution to journalArticlepeer-review


The first enantioselective total synthesis of (S)-equol is reported. The described route relies on an Evans alkylation to form the stereocenter and an intramolecular Buchwald etherification to generate the chroman ring. Key features of this method include its brevity, its scalability, and the low cost of starting materials.

Original languageEnglish (US)
Pages (from-to)5441-5443
Number of pages3
JournalOrganic Letters
Issue number24
StatePublished - Nov 23 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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