Total synthesis of RK-397

Scott E Denmark, Shinji Fujimori

Research output: Contribution to journalArticlepeer-review


An enantioselective synthesis of the polyene macrolide RK-397 is described. The use of the same eight-carbon building block twice for the construction of the polyol chain allowed for a highly convergent synthesis. The synthesis highlights stereoselective vinylogous aldol addition using a chiral bisphosphoramide as well as a sequential palladium-catalyzed cross-coupling reaction for the preparation of key fragments.

Original languageEnglish (US)
Pages (from-to)8971-8973
Number of pages3
JournalJournal of the American Chemical Society
Issue number25
StatePublished - Jun 29 2005

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


Dive into the research topics of 'Total synthesis of RK-397'. Together they form a unique fingerprint.

Cite this