Abstract
An enantioselective synthesis of the polyene macrolide RK-397 is described. The use of the same eight-carbon building block twice for the construction of the polyol chain allowed for a highly convergent synthesis. The synthesis highlights stereoselective vinylogous aldol addition using a chiral bisphosphoramide as well as a sequential palladium-catalyzed cross-coupling reaction for the preparation of key fragments.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8971-8973 |
| Number of pages | 3 |
| Journal | Journal of the American Chemical Society |
| Volume | 127 |
| Issue number | 25 |
| DOIs | |
| State | Published - Jun 29 2005 |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry