Total synthesis of hirsutellone B

K. C. Nicolaou, David Sarlah, T. Robert Wu, Weiqiang Zhan

Research output: Contribution to journalArticlepeer-review


Cascading reactions, including the conversion of a TMSepoxy tetraene 1 into the hirsutellone tricyclic core 2, feature heavily in the first total synthesis of the antituberculosis fungal metabolite hirsutellone B. TMS=trimethylsilyl, LA=Lewis acid.

Original languageEnglish (US)
Pages (from-to)6870-6874
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number37
StatePublished - Sep 1 2009
Externally publishedYes


  • Antituberculosis
  • Cascade reactions
  • Natural product
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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