Total synthesis of (+)-brasilenyne. Application of an intramolecular silicon-assisted cross-coupling reaction

Scott E. Denmark, Shyh Ming Yang

Research output: Contribution to journalArticle

Abstract

The first enantioselective total synthesis of (+)-brasilenyne (1) has been achieved in 19 linear steps, with 5.1% overall yield from L-(S)-malic acid. The construction of the oxonin core containing a 1,3-cis, cis diene unit was accomplished with a tandem ring-closing metathesis/silicon-assisted intramolecular cross-coupling reaction. In addition, a key propargylic stereogenic center was created through a novel, highly diastereoselective ring opening of a 1,3-dioxolanone promoted by TiCl4. This reaction proceeded through an oxocarbenium ion intermediate and the asymmetric induction was fully controlled by L-malic acid residue. The C(8) stereogenic center was set by a reagent-controlled asymmetric allylboration.

Original languageEnglish (US)
Pages (from-to)12432-12440
Number of pages9
JournalJournal of the American Chemical Society
Volume126
Issue number39
DOIs
StatePublished - Oct 6 2004

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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