Total synthesis and revised structure of biyouyanagin A

K. C. Nicolaou, David Sarlah, David M. Shaw

Research output: Contribution to journalArticlepeer-review


(Chemical Equation Presented) It all adds up: A 12-step total synthesis of biyouyanagin A, an inhibitor of HIV replication, has revealed its structure, rendered it available for biological investigations, and allows the synthesis of analogues. The convergent synthesis involves two cascade sequences and a remarkably selective [2+2] cycloaddition reaction to forge the cyclobutane ring of the target molecule in the ultimate step.

Original languageEnglish (US)
Pages (from-to)4708-4711
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number25
StatePublished - 2007
Externally publishedYes


  • Domino reactions
  • Inhibitors
  • Photocycloaddition
  • Structure elucidation
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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