Abstract
(Chemical Equation Presented) It all adds up: A 12-step total synthesis of biyouyanagin A, an inhibitor of HIV replication, has revealed its structure, rendered it available for biological investigations, and allows the synthesis of analogues. The convergent synthesis involves two cascade sequences and a remarkably selective [2+2] cycloaddition reaction to forge the cyclobutane ring of the target molecule in the ultimate step.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4708-4711 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 46 |
| Issue number | 25 |
| DOIs | |
| State | Published - 2007 |
| Externally published | Yes |
Keywords
- Domino reactions
- Inhibitors
- Photocycloaddition
- Structure elucidation
- Total synthesis
ASJC Scopus subject areas
- Catalysis
- General Chemistry