Topical Review: The Emerging Field of Epigenetics: Informing Models of Pediatric Trauma and Physical Health

Nicole R. Nugent, Amy Goldberg, Monica Uddin

Research output: Contribution to journalReview article

Abstract

Objective Trauma experienced during childhood and adolescence has been linked to a number of chronic medical concerns. We highlight major findings from the pediatric trauma literature to provide a model for understanding this association. Methods Studies examining the effects of trauma were systematically reviewed and synthesized into a model proposing a central role for epigenetics in the ways that childhood experiences can affect health. Results Early hypothalamic pituitary adrenal (HPA) axis response may impact initial trauma experience, with downstream effects on posttrauma adjustment reflected in posttrauma neurobiology, psychological health, and physical health. Conclusions Prospective research with children and adolescents exposed to trauma is needed to better characterize the genetic and epigenetic influences on the course of HPA and immune processes as related to posttrauma psychological and physical health outcomes.

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalJournal of Pediatric Psychology
Volume41
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • adjustment
  • genetics and genetic disorders
  • posttraumatic stress

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology

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