Abstract
Objective Trauma experienced during childhood and adolescence has been linked to a number of chronic medical concerns. We highlight major findings from the pediatric trauma literature to provide a model for understanding this association. Methods Studies examining the effects of trauma were systematically reviewed and synthesized into a model proposing a central role for epigenetics in the ways that childhood experiences can affect health. Results Early hypothalamic pituitary adrenal (HPA) axis response may impact initial trauma experience, with downstream effects on posttrauma adjustment reflected in posttrauma neurobiology, psychological health, and physical health. Conclusions Prospective research with children and adolescents exposed to trauma is needed to better characterize the genetic and epigenetic influences on the course of HPA and immune processes as related to posttrauma psychological and physical health outcomes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 55-64 |
| Number of pages | 10 |
| Journal | Journal of Pediatric Psychology |
| Volume | 41 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2016 |
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Keywords
- adjustment
- genetics and genetic disorders
- posttraumatic stress
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Developmental and Educational Psychology
Cite this
Topical Review : The Emerging Field of Epigenetics: Informing Models of Pediatric Trauma and Physical Health. / Nugent, Nicole R.; Goldberg, Amy; Uddin, Monica.
In: Journal of Pediatric Psychology, Vol. 41, No. 1, 01.01.2016, p. 55-64.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Topical Review
T2 - The Emerging Field of Epigenetics: Informing Models of Pediatric Trauma and Physical Health
AU - Nugent, Nicole R.
AU - Goldberg, Amy
AU - Uddin, Monica
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Objective Trauma experienced during childhood and adolescence has been linked to a number of chronic medical concerns. We highlight major findings from the pediatric trauma literature to provide a model for understanding this association. Methods Studies examining the effects of trauma were systematically reviewed and synthesized into a model proposing a central role for epigenetics in the ways that childhood experiences can affect health. Results Early hypothalamic pituitary adrenal (HPA) axis response may impact initial trauma experience, with downstream effects on posttrauma adjustment reflected in posttrauma neurobiology, psychological health, and physical health. Conclusions Prospective research with children and adolescents exposed to trauma is needed to better characterize the genetic and epigenetic influences on the course of HPA and immune processes as related to posttrauma psychological and physical health outcomes.
AB - Objective Trauma experienced during childhood and adolescence has been linked to a number of chronic medical concerns. We highlight major findings from the pediatric trauma literature to provide a model for understanding this association. Methods Studies examining the effects of trauma were systematically reviewed and synthesized into a model proposing a central role for epigenetics in the ways that childhood experiences can affect health. Results Early hypothalamic pituitary adrenal (HPA) axis response may impact initial trauma experience, with downstream effects on posttrauma adjustment reflected in posttrauma neurobiology, psychological health, and physical health. Conclusions Prospective research with children and adolescents exposed to trauma is needed to better characterize the genetic and epigenetic influences on the course of HPA and immune processes as related to posttrauma psychological and physical health outcomes.
KW - adjustment
KW - genetics and genetic disorders
KW - posttraumatic stress
UR - http://www.scopus.com/inward/record.url?scp=84968712591&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84968712591&partnerID=8YFLogxK
U2 - 10.1093/jpepsy/jsv018
DO - 10.1093/jpepsy/jsv018
M3 - Review article
C2 - 25825520
AN - SCOPUS:84968712591
VL - 41
SP - 55
EP - 64
JO - Journal of Pediatric Psychology
JF - Journal of Pediatric Psychology
SN - 0146-8693
IS - 1
ER -